Available Technology
CD1-deficient mouse
Technology:
Research mouse
Markets Addressed
This mouse can be used to support research in areas such as immunology and inflammation.
Innovations and Advantages
Mice homozygous for the Cd1tm1Gru targeted mutation are deficient in both the Cd1d1 and Cd1d2 genes (CD1.1, CD1.2). Homozygous mutant mice lack the normal natural killer cell -like T cell subset. However, type 2 T helper cell (TH2) response is normal, demonstrating that this T cell subset is not required for TH2 response, as previously believed.
Additional Information
Cd1d1-Cd1d2-deficient mice are available through Jackson Laboratory JAX 003814.
JAX 002962.
Use of mice by companies or for-profit entities requires a separate commercial license from Harvard University.
Publication:
Smiley ST; Kaplan MH; Grusby MJ. 1997. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science, 275(5302):977-9
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Inventor(s):
Grusby, Michael J.
Smiley, Stephen T.
Categories:
For further information, please contact:
Debra Peattie, Director of Business Development
(617) 495-3067
Reference Harvard Case #3350