Available Technology
Anti-Dscam monoclonal antibodies for studying the establishment of neural circuits
Technology:
Anti-Dscam antibodies
Markets Addressed
Anti-Dscam antibodies have been tested in western blot, immunohistochemistry, and ELISA.
License opportunity for non-exclusive research-use of Dscam monoclonal antibodies and hybridomas for generating the antibodies are available.
Innovations and Advantages
The Dscam family of immunoglobulin cell surface proteins mediates recognition events between neurons that play an essential role in the establishment of neural circuits in many organisms. Yamagata and Sanes (2008) used the chick retina as a model system for analyzing cell recognition molecules that play a role in layer-specific targeting. Interneurons form synaptic connections with retinal ganglion cells in specific layers. DSCAM and DSCAM-L are expressed in different subsets of interneurons and ganglion cells. Interestingly, interneurons and ganglion cells that target to the same layer express the same DSCAM protein. The study has suggested that DSCAM proteins promote layer-specific targeting in the chick visual system through promoting homophilic adhesion.
1. Anti-Dscam (DS2-44)
- Antibody against extracellular domain of chick Dscam, mouse IgG1 monoclonal DS2-44
2. Anti-DscamL (DS1-96)
- Antibody against extracellular domain of chick DscamL, mouse IgG1 monoclonal DS1-96
3. Anti-Dscam (DS2-176)
- Antibody against cytoplasmic domain of chick Dscam , mouse IgG1 monoclonal DS2-176
Additional Information
Publication:
Masahito Yamagata and Joshua R. Sanes. 2008. Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina. Nature (451), 465-469.
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Inventor(s):
Sanes, Joshua R.
Yamagata, Masahito
Categories:
For further information, please contact:
Debra Peattie, Director of Business Development
(617) 495-3067
Reference Harvard Case #3263