Available Technology
Anti-SAD-A monoclonal antibody for studying pre-synaptic differentiation and neuronal polarization
Technology:
Monoclonal antibody
Innovations and Advantages
Synapses of amphids defective (SAD-A), mammalian ortholog of a kinase are needed for pre-synaptic differentiation in Caenorhabditis elegans and are also required for neuronal polarization in mammals. These kinases provide entry points for unraveling signaling mechanisms that polarize neurons. SAD-A is expressed in the brain.
This invention is an anti-SAD-A monoclonal antibody against mouse SAD-A (Genbank accession number AY533672), mouse IgG1 monoclonal.
Additional Information
Anti-SAD-A antibody has been tested with mice samples by western blot and immunohistochemistry.
Opportunity for a non-exclusive research-use license of anti-SAD-A monoclonal antibody is available.
Publication:
Kishi M, Pan YA, Crump JG, Sanes JR. 2005. Mammalian SAD kinases are required for neuronal polarization. Science. 307(5711):929-932.
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Inventor(s):
Kishi, Masashi
Sanes, Joshua R.
Categories:
For further information, please contact:
Debra Peattie, Director of Business Development
(617) 495-3067
Reference Harvard Case #2756