Available Technology
Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")
Technology:
Extension of Harvard Case #1348 - extends the polony technology to provided miniaturized, high-density, bead-based nucleic acid arrays
Markets Addressed
Clinical diagnostics; food and environmental testing; research use (genomics; drug development; general biology).
Innovations and Advantages
Foundational work of Dr. George Church has enabled the production and use of replicable arrays of polymerase-amplified nucleic acid colonies (so-called "polonies") on semisolid support matrices (see Harvard Case #1438). The present invention extends the polony technology to provided miniaturized, high-density, bead-based nucleic acid arrays and improved methods for array-based sequencing of nucleic acids. High feature resolution enables identification and isolation of clonal sequences present on microparticles in both research and diagnostics applications.
Additional Information
Intellectual Property Status: The invention is available for non-exclusive license for (i) internal research use and (ii) the commercial distribution of clinical diagnostic, food testing and environmental testing products and services. U.S. and foreign patent rights are available.
Tweet
Inventor(s):
Church, George M.
Porreca, Gregory J.
Shendure, Jay A.
Zhu, Jun
Categories:
For further information, please contact:
Maryanne Fenerjian, Director of Business Development
(617) 432-0920
Reference Harvard Case #2258