Animal model of diabetes and obesity
Cross-bred JNK1 KO/JNK 2 KO Mice
These mice are a research tool that can be used to screen therapeutic compounds for efficacy in diabetes and obesity.
Innovations and Advantages
Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and obesity. These mice exhibit many of the hallmark metabolic pertubations characteristic in diabetes and obesity.
-Nature: Vol 420, Nov 21, 2002, pp 333-336
Hotamisligil, Gokhan S.
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Vivian Berlin, Director of Business Development
Reference Harvard Case #2170