Transgenic mouse model for neurodegenerative disease
Inducuble transgenic (Tg) mouse line overexpressing GFP tagged p25
Disease model useful in evaluation of potential Alzheimer's therapeutics.
Innovations and Advantages
The laboratory of Dr. Li-Huei Tsai has developed a mouse model for Alzheimers disease. They created an indicuble transgenic (Tg) mouse line overexpressing GFP tagged p25. The overexpression is restricted to the post-natal forebrain resulting in two- to three-fold incerased cdk5 activity. This in turn leads to progressive neoronal loss in the cerebral cortex and hippocampus of the Tg mice. Hyperphosphorylation and insoluble aggregation of nedogenous mouse tau are also evident.
The research group further showed that progression of the neoropathology can be halted by inhibiting p25-GFP expression.
This case is related to Harvard Case 1999.
-Cruz et al., Neuron, Vol. 40, 471-483, October 30, 2003.
Cruz, Jonathan C.
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Michal Preminger, Director of Business Development
Reference Harvard Case #2161