Available Technology
Modulating gene activity on chondrocytes
Technology:
Col 2A promoter Cre transgenic mice
Markets Addressed
Research tool and animal model for the study of chondrocytes and arthritis
Innovations and Advantages
Transgenic mice were generated in which the regulatory sequences for the Col2a1 gene were used to drive expression of Cre recombinase in chondrocytes. The strain initiates Cre-mediated recombination predominantly in immature chondrocytes and the inner layer of perichondrial cells within the developing endochondral skeleton . However, there is also significant Cre-activity in other regions of the embryo reflecting the widespread expression of Col2a1.
Additional Information
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Inventor(s):
Long, Fanxin
McMahon, Andrew P.
Categories:
For further information, please contact:
Vivian Berlin, Director of Business Development
(617) 496-0474
Reference Harvard Case #2144