Available Technology
Hyperactive mutant of the Himar1 mariner transposase
Technology:
Himar1 element
Markets Addressed
Microbial engineering for research or manufacturing uses.
Innovations and Advantages
Mariner-family transposable elements are active in a wide variety of organisms, and therefore, are important genetic engineering tools. The Himar1 element, isolated from the horn fly, Haematobia irritans, has been shown to be active in E. coli. Hyperactive variants of the corresponding transposase have been isolated. These proteins retain their hyperactivity and are useful both in vivo and in vitro as research tools and in cell-based manufacturing processes.
Additional Information
Intellectual Property Status: The invention is protected under U.S. Patent No. 6,368,830, which is available for non-exclusive license.
Publication:
-Lampe et al., 1999, Proc. Natl. Acad. Sci. USA 96(20): 11428-33.
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Inventor(s):
Akerley, Brian J.
Lampe, David J.
Robertson, Hugh M.
Rubin, Eric Joseph
Categories:
For further information, please contact:
Debra Peattie, Director of Business Development
(617) 495-3067
Reference Harvard Case #1740