Available Technology
A genetically modified herpes simplex virus that has utility as a drug screening tool
Technology:
Drug screening tool for herpes antivirals
Markets Addressed
Antiviral drug screen
Innovations and Advantages
Harvard Medical School researchers have developed a genetically modified herpes simplex virus that has utility as a drug screening tool. To develop this tool, Harvard researchers engineered a replication competent herpes virus that contains green fluorescent protein (GFP) fused to a viral replication protein. During replication, this modified protein is transcribed and translated such that its expression can be detected by fluorescence of the GFP. As a result, drug candidates that affect herpes replication or the expression of this protein can be identified by changes in the level of fluorescence.
Additional Information
Intellectual Property Status: Issued U.S. patent nos.: 6,399,354
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Inventor(s):
Knipe, David M.
McNamee, Elizabeth E.
Taylor, Travis
Categories:
For further information, please contact:
Michal Preminger, Director of Business Development
(617) 432-0920
Reference Harvard Case #1546