Available Technology
Surface-bound double-stranded DNA protein arrays
Technology:
Nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions between proteins and nucleic acid molecules
Markets Addressed
Proteomics and pharmacogenomics research; drug development; clinical diagnostic, food and environmental testing.
Innovations and Advantages
Developed at Harvard Medical School, this invention provides nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions between proteins and nucleic acid molecules. Intermolecular analyses enabled by this technology are advantageously performed in massively-parallel fashion under uniform reaction conditions. This technology enables researchers to:
- Screen for polypeptides that bind nucleic acid sequences of interest.
- Highlight potential gene regulatory elements.
- Identify candidate co-regulated genes based upon their affinity for a given trans-regulator.
- Identify nucleotides or amino acids that mediate specific DNA:protein or protein:protein interactions.
Additional Information
- Internal research use
- Commercial service use
- Sale of information generated through use of methods
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Inventor(s):
Bulyk, Martha L.
Church, George M.
Categories:
For further information, please contact:
Maryanne Fenerjian, Director of Business Development
(617) 432-0920
Reference Harvard Case #1439