Available Technology
Rapid synthesis of radiolabeled pyrimidine nucleosides or nucleotides from Stann
Technology:
Kit for the production of radiolabeled nucleosides or nucleotides
Markets Addressed
The present invention provides a kit for the production of radiolabeled nucleosides or nucleotides. The kit comprises a premeasured amount of trialkylstannylated nucleoside or nucleotide precursor, such as for example, 5-trimethylstannyl-2' -deoxyuridine or 5-tributylstannyl-2' -deoxyuridine in a sterilized container and a premeasured amount of the oxidative solution in a second sterilized container. Ina preferred embodiment, the precursor, e.g., Bu3SnUdR, is complexed with a carrier molecule, e.g., bound to the surface of beads of a test tube. Such kits are particularly useful for clinical applications.
Innovations and Advantages
The radiolabeling conditions of trialkylstannyl nucleosides and nucleotides have been studied using UdR as a model compound to identify the reaction conditions that lead to the rapid production of no-carrier added radioiodinated nucleosides and nucleotides, the sampling being void of all UV-contaminating species. Thus, the method of this invention enables the production of no-carrier-added radiolabeled nucleosides or nucleotides such as radiohalogenated deoxyurindine, with out UV-contaminating species such as tin percursors, e.g., trialkystannyl UdR, etc. The present invention provides a method for the rapid synthesis of radiolabeled nucleosides or nucleotides for biological or clinical use.
Additional Information
Intellectual Property Status: Issued U.S. patent nos.: 5,720,935
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Inventor(s):
Adelstein, S. James
Foulon, Catherine F.
Kassis, Amin I.
Categories:
For further information, please contact:
Grant Zimmermann, Director of Business Development
(617) 495-3067
Reference Harvard Case #1169