Vaccines that comprise attenuated pathogens
Genetically attenuated microbial vaccines
Improved cell-based vaccines
Innovations and Advantages
The invention provides vaccines that comprise attenuated pathogens and methods for the creation of attenuated microorganisms useful in such vaccines. It also encompasses methods for the creation of attenuated microorganisms useful in such vaccines. As claimed, attenuation of the organism against which the vaccine is to be directed in a recipient host is attributable to a combination of mutations. The first such mutation produces an auxotrophic condition, such that the microorganism requires a nutrient to proliferate, while a second mutation disables a mechanism specific for transport of that nutrient into the microorganism. While neither mutation alone attenuates the pathogenic microorganism, the two together render it incapable of causing disease in the vaccinated host.
Intellectual Property Status:
U.S. Patent No. 6,254,874 is available on a field-exclusive basis for human and veterinary healthcare and on a non-exclusive basis for internal research use.
Mekalanos, John J.
For further information, please contact:
Michal Preminger, Director of Business Development
Reference Harvard Case #1034