Available Technology
Hydroxapatite-antigen conjugates and methods for generating a poly-Ig immune response
Technology:
Method for generating antigen-sensitized Ig-A-producing lymphoblasts in a mammal
Markets Addressed
Vaccines and methods of vaccinating
Innovations and Advantages
We have discovered that hydroxylated calcium phosphate (HCP) particulate is a particularly useful carrier for antigens to be applied to mucosal surfaces. The antigen-HCP conjugate is transported across epithelium where it raises a poly Ig immune response.
One aspect of the invention generally features a method for generating antigen-sensitized Ig-A-producing lymphoblasts in a mammal. In that method, an immunogen comprising an antigen or antigen mixture in association with hydroxylated calcium phosphate (HCP) particulate is administered to a mucosal surface of the mammal. In preferred embodiments of this first aspect of the invention, the antigen-sensitized lymphoblasts are recovered and immortalized to yield an Ig-A producing hybridoma.
A second aspect of the invention features a method for vaccinating a mammal (especially a human) comprising administering the above-described immunogen to a mucosal surface of the mammal.
A third aspect of the invention features an immunogen comprising an antigen or antigen mixture in association with hydroxylated calcium phosphate particles of a size suitable for transport across epithelium.
Additional Information
Intellectual Property Status: Issued U.S. patent 5,443,832
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Inventor(s):
Amerongen, Helen
Kraehenbuhl, Jean-Pierre
Neutra, Marian R.
Categories:
For further information, please contact:
Michal Preminger, Director of Business Development
(617) 432-0920
Reference Harvard Case #0641