Access: If you want to use Cre-Lox Technlogy
The agreement displayed below is also available for viewing/download as a PDF file.
What to do if you want to use the Cre-lox technology
Contact: Office of Technology Development (OTD)
Efrat Shalom-Berensohn: 617-495-4375.
Provide the following information:
A brief description of the research to be conducted;
Funding sources to be used to support that research;
The source of any third-party materials to be used in that research.
Sign below to confirm that you understand and will abide by the terms of the BMS license agreement including the following limitations:
investigators cannot use cre DNA and/or lox DNA in higher plants or agricultural applications;
investigators cannot use cre DNA and/or lox DNA in the alteration of mouse embryonic stem cells or other pluripotential mouse cells for the purpose of preparing a library of such mouse embryonic stem cells or other pluripotential mouse cells containing cre DNA and/or lox DNA;
investigators cannot use any material containing cre DNA and/or lox DNA for 'any commercial purpose' or for the 'benefit of any for-profit institution' - thus the Cre-lox technology cannot generally be used in any research sponsored by a for-profit source or in research using biological materials received from a for-profit source;
investigators cannot provide any material containing cre DNA and/or lox DNA to others (whether to a non-profit or to a for-profit institution) except under specific conditions and under a special Material Transfer Agreement.
If you want to use the technology for 2a, 2b, or 2c above, ask OTD to attempt to obtain additional rights from BMS.
If you want to-send cre or lox materials to a non-profit, contact OTD to confirm that the recipient institution has a BMS license and to obtain the MTA that must be used for the transfer. This agreement must be signed on behalf of Harvard by either the Director of OTD and must be signed by both the recipient scientist and an authorized official of his/her institution. The fully signed agreement must be on file with OTD before the materials are transferred.
If you want to send cre or lox materials to a for-profit organization, contact OTD since a special agreement will need to be negotiated and the for-profit must have a license from BMS and must pay BMS a fee.
Upon BMS's request, you will have to provide BMS with 'reasonable quantities' of any materials made using the Cre-lox technology. BMS will only be permitted to use these materials for research purposes.
UNDERSTOOD AND AGREED:
[Signature] [Date]
Attach the information requested in item 1 and return a signed copy of this document to:
OTD
Harvard Medical School
25 Shattuck Street
Gordon Hall of Medicine, Room 414
Boston, MA 02115
or to
OTD
Holyoke Center, Suite 727
1350 Massachusetts Ave.
Cambridge, MA 02138
The agreement displayed above is also available for viewing/download as a PDF file.