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AVAILABLE TECHNOLOGIES - Research Tools

Results: 99
Case # Lead Inventor Title
4494Paulsson, JohanMicrofluidics Assisted Cell Screening
4493Paulsson, JohanCreating a new generation of monomeric flurescent proteins
4406Hochschild, AnnBacteria based PrP and Amyloid technology generates novel aggregation assays
4396Datta, Sandeep RobertMapping the Behaviorome: Comprehensive, quantitative, and unbiased visualization of defined behavior states
4342Mekalanos, John J.High efficency di-nucleotide cyclase
4238Eggan, Kevin CarlInduced motor neurons (iMNs)
4223Salic, AdrianMethod for imaging and identifying newly synthesized proteins in vivo
4197Liu, David R.Directed evolution of bond-forming enzymes using yeast display: application to sortase A
4095Park, HongkunLow voltage nanowire-based electroporation of cells
4086Liu, David R.Zinc-finger nucleases: determining and improving target sequence specificity
3826Cohen, Adam E.A fast, sensitive optical indicator for membrane potential in cells
3786Mooney, David J.Materials presenting Notch signaling molecules to control cell behavior
3760Doyle, John M.Analyzing trace gases at part per billion levels by rapid gas phase cooling
3733Whitesides, George M.Uniform phage display amplification in droplets
3718Whitesides, George M.3D cell culture substrate that enables live-cell imaging
3678Colaiacovo, Monica P.High-throughput screening tools for environmental disruptors of meiosis and fat homeostasis
3605Melton, DouglasIDE1 and IDE2, small molecule inducers of definitive endoderm from mouse and human embryonic stem cells
3602Olsen, Bjorn R.Vascular endothelial transdifferentiation to mesenchymal stem-like cells
3580Liu, David R.Interaction-dependent PCR: Multiplexed identification of ligand-target pairs from DNA-encoded ligand/target libraries in a single solution-phase experiment
3538Sabatini, BernardoPhotoactivatable opoid neuropeptides
3507Lieber, Charles M.Localized bioprobes for electrophysiology
3495Wu, Chao-tingOligopaints as a means for marking chromosomes with superior resolution and labeling functionality
3473Nagai, ShigemiOsteoinductive peptides to enhance bone regeneration
3468Crozier, Kenneth B.The SMALL Microscope: Scanning microscopy on a chip
3466Mazur, EricFast, accurate, laser-based cell injection technique
3437Salic, AdrianMetabolic labeling and direct imaging of choline-containing phospholipids in vivo
3350Grusby, Michael J.CD1-deficient mouse
3330Eggan, Kevin CarlEfficient induction of pluripotent stem cells using small molecule compounds: RepSox
3326Liu, David R.A system for the continuous directed evolution of biomolecules
3312Melton, DouglasMethods of direct reprogramming: converting pancreatic exocrine cells to beta cells
3263Sanes, Joshua R.Anti-Dscam monoclonal antibodies for studying the establishment of neural circuits
3231Whitesides, George M.Paper-supported 3D cell culture for cell and tissue-based bioassays
3211Park, HongkunVertical silicon nanowires as a universal platform for highly efficient delivery of bioactive molecules into living cells
3205Eggan, Kevin CarlInduced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
3198Prentiss, Mara G.New cell sorting technology could replace fluorescent and magnetic technologies
3197Melton, DouglasUsing (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage
3175Tschumperlin, Daniel J.High-throughput hydrogel-based 2D platform for culturing cells in realistic tissue stiffness environments
3152Melton, DouglasEfficient induction of pluripotent stem cells using small molecule compounds
3146Mazitschek, RalphHDAC substrate is ideally suited to HDAC 4, 5, 7, 8 and 9 enzyme activity assays
3086Corey, David P.TRPA1 constitutive and conditional knockout mice
3045Crozier, Kenneth B.Optical tweezers get smaller, sharper, and less expensive
2983Fredberg, JeffreyRealistic reproduction of a cell's dynamic physical environment
2963Gygi, Steven P.Mass spectrometry-based in vitro kinome activity assay
2956Roth, Frederick P.Methods and applications for stitched DNA barcodes
2889Sanes, Joshua R.Corticospinal tract (CST)-YFP transgenic mice for monitoring axonal responses to spinal cord injury
2807Maniatis, ThomasHomozygous IKKepsilon knockout mouse as an animal model for influenza virus infection
2756Sanes, Joshua R.Anti-SAD-A monoclonal antibody for studying pre-synaptic differentiation and neuronal polarization
2681Wessling-Resnick, MarianneHEK293T cells stably express Divalent Metal Transporter-1 for use in a model system to screen for inhibitors of iron uptake
2633Pizzagalli, Diego A.Software for early detection and assessment of depression
2612Lichtman, Jeffrey W.Transgenic mice with fluorescently tagged neuronal mitochondria as a new tool to study axonal transport
2611Lichtman, Jeffrey W.Brainbow mice: A technicolor approach to map the neuronal circuits
2559McMahon, Andrew P.A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo
2436Schreiber, Stuart L.Tubacin - a specific small molecule inhibitor of HDAC6 tubulin deacetylase activity
2384Nibert, Max L.Determination of intracellular protein-protein interactions
2334Liu, David R.Small-molecule-triggered intein splicing as a universal switch for protein activation
2307Church, George M.Enhanced fidelity of sub-nanogram amplification
2261Church, George M.Modular conditional knockout: Precise temporal control of protein degradation in living cells
2258Church, George M.Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")
2212Dowling, John E.Using Zebrafish for clues about human vision loss
2203Kobzik, LesterMonoclonal IgE anti-ovalbumin antibody
2193Myers, Andrew G.A novel assay for identifying biological targets of DNA binding agents
2170Hotamisligil, Gokhan S.Animal model of diabetes and obesity
2163Liu, David R.Drug-inducible RNA aptaswitch for regulating eukaryotic protein expression
2161Tsai, Li-HueiTransgenic mouse model for neurodegenerative disease
2144McMahon, Andrew P.Modulating gene activity on chondrocytes
2060Schreiber, Stuart L.Anti-mitotic Eg5 inhibitors for the treatment of cancer and inflammatory disease
2025Liu, David R.In vivo selection systems for evolving the specificity of endonucleases and inteins
2024Church, George M.MicroArray spot LINEar regression (MASLINER) software
1947Roth, Frederick P.GoFish gene annotation and database query software
1918Gygi, Steven P.Absolute quantification of Proteins (AQUA)
1917Schreiber, Stuart L.Tubacin - a specific small molecule inhibitor of HDAC6 tubulin deacetylase activity
1885Liu, David R.Directed evolution of proteins and nucleic acids using nonhomologous random recombination
1884Gygi, Steven P.Microcapillary column peptide trap provides superior mechanical design to the automated loader
1882Myrick, Kyl V.A versatile method for accelerated chromosome walking and DNA fingerprinting
1833Kobzik, LesterAnti-PLK-1 monoclonal antibody
1823Verdine, Gregory L.A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research
1821Church, George M.Time and concentration warping software for RNA and protein expression data
1816Lieber, Charles M.High-yield fabrication of single-walled carbon nanotube probe tips for atomic force microscopy
1740Rubin, Eric JosephHyperactive mutant of the Himar1 mariner transposase
1699Kim, TaeKookp53 cell-Based assay
1690Shair, Matthew D.Ultra fast method for chiral catalyst discovery
1675Schreiber, Stuart L.Human Histone Deacetylase (HDAC) Class II
1587David, John R.Migration inhibitory factor (MIF) knockout mouse
1534Howley, Peter M.Selectively degrading specific cellular proteins
1528Hogle, James M.A tool for the linkage and presentation of multiple protein functional domains
1490Wilcox, Heather M.Monoclonal antibody 2F12, Anti-ITK
1487Schreiber, Stuart L.High-throughput synthetic platform for natural product analog libraries
1452Shi, ChengweiCellular basis of vascular-graft stenosis
1451Church, George M.AlignAce motif searching software
1441Glimcher, LaurieTranscription HXBP-1 factor fragment
1439Church, George M.Surface-bound double-stranded DNA protein arrays
1438Church, George M.Production and uses of polymerase colony ("polony") arrays
1426Struhl, KevinA rapid and inducible method for repressing gene function
1391Melton, DouglasCell-based assay for the discovery of glycogen synthase kinase inhibitors
1250Schreiber, Stuart L.Human Histone Deacetylase (HDAC) Class I
1246Lee, Arthur Mu-EnMediator of arterial smooth muscle cell LIM protein
1119Leder, PhilipEotaxin: an eosinophil chemoattractant
0806Essex, Myron EA method for producing partially deglycosylated HIV-1 envelope glycoproteins through site-directed mutagenesis
0627Berson, EliotProbe compositions and relevant animal models used to evaluate the pathogenesis of retinitis pigmentosa and potentially new therapeutic modalities