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Therapeutics/Vaccines

AVAILABLE TECHNOLOGIES

Results: 67
Case # Lead Inventor Title
4768Haigis, Marcia C.Inhibiting long chain fatty acid oxidation for the treatment of cancer
4342Mekalanos, John J.High efficency di-nucleotide cyclase
4316Mooney, David J.Controlled delivery of TLR agonists in structural polymeric devices
4188Haigis, Marcia C.Cancer Metabolism: SIRT4 as a Key Regulator of Glutamine Metabolism
4158Aktas, HuseyinSmall molecule modulators of ER Stress: Targeting the eIF2a Ternary Complex
4090Losick, RichardPolyamines inhibit bacterial biofilm formation
4086Liu, David R.Zinc-finger nucleases: determining and improving target sequence specificity
4018Collier, R. JohnDelivery of bioactive compounds using a transporter domain of engineered bacterial proteins
3843Liu, David R.Small-molecule macrocycles: Potent and selective Src kinase inhibitors
3787Maniatis, ThomasCardiac glycosides as treatments for inflammatory and autoimmune diseases
3755Kasper, DennisSmall molecule inhibitors of Ebola virus entry
3700Myers, Andrew G.Trioxacarcins and analogs: DNA-modifying compounds with potent anti-proliferative effects
3696Lu, QuanNew therapeutic targets for the treatment of asthma and COPD
3681Artavanis-Tsakonas, SpyrosModulators of notch dimerization and receptor signalling
3572Jacobsen, Eric N.Practical, scaleable method of making optically pure unnatural amino acids provide new set of intermediates for research and commercial use
3549Greenberg, Michael ENovel target for Angelman Syndrome and Autism Spectrum Disorders
3439Aktas, HuseyinSmall molecule activators of HRI kinase: A new class of anti-cancer therapeutics and biomarker for cancer patient selection
3438Walker Kahne, SuzannePotent OGT inhibitors for the treatment of cancer and diabetic complications
3391Mooney, David J.On-demand and reversible drug release by external cue
3378Rubin, Lee L.Methods and compounds for the treatments of spinal muscular atrophy and ALS
3358Corey, Elias J.Next generation therapeutics for macular degeneration and cancer
3289Hu, GuofuUse of neamine for treating prostate cancer
3283King, Randall W.Small molecule inhibitor of Cdc20 induces mitotic arrest
3242Walker Kahne, SuzanneTargocil: Novel antibiotics against Methicillin-resistant Staphylococcus aureus (MRSA)
3219Myers, Andrew G.Synthetic route for anti-angiogenic natural products cortistatins and analogs
3216Schreiber, Stuart L.Robotnikinin: small molecule inhibitor of sonic hedgehog (Shh) signaling in human cells
3133Harrison, Stephen C.A fusion intermediate state of HIV-1 gp41, targeted by broadly neutralizing antibodies, for purposes of vaccination
3094Cepko, Constance L.Protection of cone cells by HDAC4 mediated Hif1alpha activation could lead to the development of new therapeutics in degenerative eye diseases
3079Auguste, Debra T.Sensitive drug pouches target tumors for chemotherapy
3048Yuan, JunyingPlatform technology for small molecule inhibitors of regulated cellular necrosis
2985Kahne, Daniel E.Development of broad spectrum antibiotics for new targets
2964Eggan, Kevin CarlIn vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)
2858Desrosiers, Ronald C.Vaccination against HIV using Herpesvirus
2715Whitesides, George M.Antibody purification
2704Walker Kahne, SuzanneDevelopment of broad spectrum antibiotics for new targets
2580Vallee, Bert L.Endowment angiogenesis-related patents
2508Kasper, DennisPrevention of tularemia using an enhanced live attenuated vaccine strain
2438Myers, Andrew G.Natural product avrainvillamide and its analogs as targeted anticancer agents
2384Nibert, Max L.Determination of intracellular protein-protein interactions
2347Coen, Donald M.Novel Anti-CMV Small Molecules
2334Liu, David R.Small-molecule-triggered intein splicing as a universal switch for protein activation
2301Goldberg, Alfred L.Novel candidates for Tuberculosis therapy
2252Rando, Robert R.Treatment of AMD by Targeting Lipocuscin
2129Verdine, Gregory L.Lead compounds for the treatment of pain
2025Liu, David R.In vivo selection systems for evolving the specificity of endonucleases and inteins
1872Kirschner, Marc W.Targeting FtsZ activity using novel antibacterials
1846Strominger, Jack L.Novel peptide therapeutic for multiple sclerosis
1798Madras, BerthaPortfolio of novel monoamine uptake inhibitors targeting monoamine transporters
1781Walsh, Christopher T.Techniques for high yield synthesis of macrocyclic compounds
1742Jones, Alun G.Next generation diagnostics for breast cancer, prostate cancer and melanoma
1659Yuan, Zhi-MinNovel means of protecting the cell against oncogenic tumor formation
1653Yuan, JunyingSmall molecule inhibitors of the Bcl-XL/Bak interaction activate the cell death pathway
1613Coen, Donald M.Inhibitors of protein-processivity factor
1603Falchuk, Kenneth H.Bilins as anticancer agents
1558Harrison, Stephen C.Vaccine compositions and methods for Human Papilloma Virus
1554Yuan, JunyingSmall molecule therapeutic for drugs against chronic neural degenerative diseases
1487Schreiber, Stuart L.High-throughput synthetic platform for natural product analog libraries
1486Howley, Peter M.Compositions and methods for treating papillomavirus-infected cells
1472Verdine, Gregory L.Synthesis of compounds with peptide characteristics
1372Whitman, Malcolm R.Methods and reagents for modulating TGF-beta superfamily signalling
1329Beverley, Stephen M.New delivery device for protein therapeutics and vaccines
1127Swanson, JoelLiposome-based, intracellular delivery of drugs into phagocytes, B- and T-cells, and their tumor cells
1119Leder, PhilipEotaxin: an eosinophil chemoattractant
1034Mekalanos, John J.Vaccines that comprise attenuated pathogens
0862Leder, PhilipCompositions and methods for the diagnosis and treatment of both malignant and benign cell-proliferative diseases
0806Essex, Myron EA method for producing partially deglycosylated HIV-1 envelope glycoproteins through site-directed mutagenesis
0641Neutra, Marian R.Hydroxapatite-antigen conjugates and methods for generating a poly-Ig immune response