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Results: 124
Case # Lead Inventor Title
4768Haigis, Marcia C.Inhibiting long chain fatty acid oxidation for the treatment of cancer
4717Wagner, GerhardA fragment based drug discovery platform ; For high throughput synthesis and screening of protein-protein inhibitors
4716Gilbert, GaryA novel assay for improved measurement of factor VIII activity
4657Benjamin, Thomas L.Assessing polyomavirus-related disease risk using genetic testing
4453Zenati, MarcoA novel team optimization system for achieving optimal performance management
4415Collier, R. JohnKilling tumor cells with a receptor-targeted bacterial toxin
4406Hochschild, AnnBacteria based PrP and Amyloid technology generates novel aggregation assays
4396Datta, Sandeep RobertMapping the Behaviorome: Comprehensive, quantitative, and unbiased visualization of defined behavior states
4370Lieber, Charles M.Cyborg tissue: Macroporous nanowire nanoelectronic scaffolds for synthetic tissues
4324Cohen, Adam E.Voltage indicator proteins and microscope for imaging rhodopsin fluorescence
4316Mooney, David J.Controlled delivery of TLR agonists in structural polymeric devices
4238Eggan, Kevin CarlInduced motor neurons (iMNs)
4226Butt, Mohamed HanifHarvard Assisted Rapid Palatal Expander (HARPE)
4188Haigis, Marcia C.Cancer Metabolism: SIRT4 as a Key Regulator of Glutamine Metabolism
4158Aktas, HuseyinSmall molecule modulators of ER Stress: Targeting the eIF2a Ternary Complex
4151Mooney, David J.Aesthetic medicine: Adipose (fat) tissue engineering using injectible hydrogels
4132Kassis, Amin I.Kits For the Isolation of Pure WBCs
4069Mathis, Diane J.Wound healing driven by unique population of muscle-specific Tregs
4068Lory, StephenDEVELOPMENT OF BROAD SPECTRUM ANTIMICROBIAL AGENTS; TARGETING THE CELL ENVELOPE BIOGENESIS PATHWAY OF GRAM-NEGATIVE; BACTERIAL PATHOGENS
3867Hotamisligil, Gokhan S.Novel lipid hormone for identifying and treating metabolic disease
3845von Andrian, Ulrich H.Bisphosphonates as novel adjuvants to enhance the adaptive immune response
3843Liu, David R.Small-molecule macrocycles: Potent and selective Src kinase inhibitors
3787Maniatis, ThomasCardiac glycosides as treatments for inflammatory and autoimmune diseases
3785Haigis, Marcia C.Regulation of hypoxia and glycolysis through modulation of SIRT3 activity: SIRT3 activators for cancer metabolism and SIRT3 inhibitors for vascular disease
3782Mooney, David J.Nanoparticle targeting to ischemia or Cancer for imaging and therapy
3755Kasper, DennisSmall molecule inhibitors of Ebola virus entry
3741McMahon, Andrew P.Modulators of hedgehog signaling
3724Brugge, Joan SiefertCombination cancer therapies to circumvent induced resistance pathways
3719Howe, Robert D.Motion compensating catheter for beating heart surgery
3700Myers, Andrew G.Trioxacarcins and analogs: DNA-modifying compounds with potent anti-proliferative effects
3692Blenis, JohnIdentification of novel downstream effectors of the mTOR1 pathway
3681Artavanis-Tsakonas, SpyrosModulators of notch dimerization and receptor signalling
3622von Andrian, Ulrich H.Novel target in NK cell mediated antigen specific memory responses
3605Melton, DouglasIDE1 and IDE2, small molecule inducers of definitive endoderm from mouse and human embryonic stem cells
3599von Andrian, Ulrich H.Naturally occurring molecule serves as a novel adjuvant to boost immune responses
3588Flanagan, John G.Increasing neural regeneration following traumatic injury: Modulation of neuronal outgrowth with HSPG (heparin) and CSPG (chondroitin)
3569Roth, Frederick P.Novel combination therapies for the treatment of cancer and inflammation
3564Struhl, KevinMetformin selectively targets cancer stem cells
3553Bean, Bruce P.Permanently charged ion channel blockers as anti-inflammatory and asthma therapeutic agents
3549Greenberg, Michael ENovel target for Angelman Syndrome and Autism Spectrum Disorders
3510Mooney, David J.Laser-induced photobiomodulation for dentin regeneration
3473Nagai, ShigemiOsteoinductive peptides to enhance bone regeneration
3469Sorger, Peter K.Knockout mouse model for human liver cancer
3461Cepko, Constance L.Gluconeogenesis as a pro-survival treatment for neurons under stress
3439Aktas, HuseyinSmall molecule activators of HRI kinase: A new class of anti-cancer therapeutics and biomarker for cancer patient selection
3438Walker Kahne, SuzannePotent OGT inhibitors for the treatment of cancer and diabetic complications
3378Rubin, Lee L.Methods and compounds for the treatments of spinal muscular atrophy and ALS
3362Hotamisligil, Gokhan S.Secreted target for type 2 diabetes and metabolic disease
3358Corey, Elias J.Next generation therapeutics for macular degeneration and cancer
3350Grusby, Michael J.CD1-deficient mouse
3312Melton, DouglasMethods of direct reprogramming: converting pancreatic exocrine cells to beta cells
3289Hu, GuofuUse of neamine for treating prostate cancer
3283King, Randall W.Small molecule inhibitor of Cdc20 induces mitotic arrest
3279Sharpe, Arlene H.Novel methods for generating regulatory T-cells
3272Beckwith, Jonathan R.Microbial VKOR as an anti-infective target
3262Hotamisligil, Gokhan S.Novel lipid hormone for identifying and treating metabolic disease
3248Girguis, Peter RiadRobust Biological Conversion of Methane to Electricity
3242Walker Kahne, SuzanneTargocil: Novel antibiotics against Methicillin-resistant Staphylococcus aureus (MRSA)
3219Myers, Andrew G.Synthetic route for anti-angiogenic natural products cortistatins and analogs
3216Schreiber, Stuart L.Robotnikinin: small molecule inhibitor of sonic hedgehog (Shh) signaling in human cells
3205Eggan, Kevin CarlInduced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
3197Melton, DouglasUsing (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage
3133Harrison, Stephen C.A fusion intermediate state of HIV-1 gp41, targeted by broadly neutralizing antibodies, for purposes of vaccination
3094Cepko, Constance L.Protection of cone cells by HDAC4 mediated Hif1alpha activation could lead to the development of new therapeutics in degenerative eye diseases
3059Bean, Bruce P.Targeting anti-cancer drugs intracellularly via TRP channels
3048Yuan, JunyingPlatform technology for small molecule inhibitors of regulated cellular necrosis
3025Schier, Alexander FRNA therapy: miRNA target protectors
3002Schachter, Steven C.Wogonin - a drug candidate for pain
2985Kahne, Daniel E.Development of broad spectrum antibiotics for new targets
2964Eggan, Kevin CarlIn vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)
2963Gygi, Steven P.Mass spectrometry-based in vitro kinome activity assay
2950Cardozo, David L.A novel source of neural stem cells
2944McMahon, Andrew P.Wnt ligands for the development of diagnostics and treatments of CNS and BBB disorders
2937Qin, XuebinApplication of Domain 4 of ILY for treatment and prevention of foreign ; pathogen infection
2911Silver, Pamela A.Protein-based therapies using quantitatively designed proteins
2889Sanes, Joshua R.Corticospinal tract (CST)-YFP transgenic mice for monitoring axonal responses to spinal cord injury
2858Desrosiers, Ronald C.Vaccination against HIV using Herpesvirus
2807Maniatis, ThomasHomozygous IKKepsilon knockout mouse as an animal model for influenza virus infection
2763Girguis, Peter RiadLow cost and versatile microbial fuel cell
2704Walker Kahne, SuzanneDevelopment of broad spectrum antibiotics for new targets
2681Wessling-Resnick, MarianneHEK293T cells stably express Divalent Metal Transporter-1 for use in a model system to screen for inhibitors of iron uptake
2633Pizzagalli, Diego A.Software for early detection and assessment of depression
2612Lichtman, Jeffrey W.Transgenic mice with fluorescently tagged neuronal mitochondria as a new tool to study axonal transport
2611Lichtman, Jeffrey W.Brainbow mice: A technicolor approach to map the neuronal circuits
2605Knipe, David M.A novel strategy for the prevention and treatment of sexually transmitted viruses
2580Vallee, Bert L.Endowment angiogenesis-related patents
2568Whelan, Sean P.J.Attenuated RNA viruses for vaccine and drug delivery
2559McMahon, Andrew P.A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo
2508Kasper, DennisPrevention of tularemia using an enhanced live attenuated vaccine strain
2438Myers, Andrew G.Natural product avrainvillamide and its analogs as targeted anticancer agents
2406Roth, Frederick P.Simultaneous study of multiple genetic interactions using multi-mutant yeast
2347Coen, Donald M.Novel Anti-CMV Small Molecules
2301Goldberg, Alfred L.Novel candidates for Tuberculosis therapy
2252Rando, Robert R.Treatment of AMD by Targeting Lipocuscin
2212Dowling, John E.Using Zebrafish for clues about human vision loss
2193Myers, Andrew G.A novel assay for identifying biological targets of DNA binding agents
2170Hotamisligil, Gokhan S.Animal model of diabetes and obesity
2144McMahon, Andrew P.Modulating gene activity on chondrocytes
2129Verdine, Gregory L.Lead compounds for the treatment of pain
2060Schreiber, Stuart L.Anti-mitotic Eg5 inhibitors for the treatment of cancer and inflammatory disease
1903Coen, Donald M.Sensitive assay to identify inhibitors of HSV DNA polymerase
1846Strominger, Jack L.Novel peptide therapeutic for multiple sclerosis
1798Madras, BerthaPortfolio of novel monoamine uptake inhibitors targeting monoamine transporters
1742Jones, Alun G.Next generation diagnostics for breast cancer, prostate cancer and melanoma
1740Rubin, Eric JosephHyperactive mutant of the Himar1 mariner transposase
1659Yuan, Zhi-MinNovel means of protecting the cell against oncogenic tumor formation
1653Yuan, JunyingSmall molecule inhibitors of the Bcl-XL/Bak interaction activate the cell death pathway
1587David, John R.Migration inhibitory factor (MIF) knockout mouse
1558Harrison, Stephen C.Vaccine compositions and methods for Human Papilloma Virus
1554Yuan, JunyingSmall molecule therapeutic for drugs against chronic neural degenerative diseases
1546Knipe, David M.A genetically modified herpes simplex virus that has utility as a drug screening tool
1475Mekalanos, John J.Systematic, condition-independent identification of essential genes of microorganisms
1452Shi, ChengweiCellular basis of vascular-graft stenosis
1391Melton, DouglasCell-based assay for the discovery of glycogen synthase kinase inhibitors
1248Wessling-Resnick, MarianneNovel compositions which modulate iron uptake in cells for the treatment of iron deficient anemias or iron overload disorders
1229Howley, Peter M.Gene therapy for papillomavirus induced cervical carcinoma
1188Wong, David T. W.Novel tumor suppressor protein and gene could be used to develop treatments of carcinoma
1173Coen, Donald M.High lead expression of soluble CMV UL97 and development of an assay to screen inhibitors
1127Swanson, JoelLiposome-based, intracellular delivery of drugs into phagocytes, B- and T-cells, and their tumor cells
1121Munger, KarlMethod and kit for evaluating transformed cells
1083Kassis, Amin I.Rapid Synthesis of Radiolabeled Pyrimidine Nucleosides or Nucleotides for Tumor or Lesion Imaging
0951Russell, MaryMethods of detecting and treating arterial inflammatory disease
0806Essex, Myron EA method for producing partially deglycosylated HIV-1 envelope glycoproteins through site-directed mutagenesis
0641Neutra, Marian R.Hydroxapatite-antigen conjugates and methods for generating a poly-Ig immune response