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Biomedical Research Tools

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Results: 159
Case # Lead Inventor Title
4717Wagner, GerhardA fragment based drug discovery platform ; For high throughput synthesis and screening of protein-protein inhibitors
4657Benjamin, Thomas L.Assessing polyomavirus-related disease risk using genetic testing
4494Paulsson, JohanMicrofluidics Assisted Cell Screening
4493Paulsson, JohanCreating a new generation of monomeric flurescent proteins
4406Hochschild, AnnBacteria based PrP and Amyloid technology generates novel aggregation assays
4396Datta, Sandeep RobertMapping the Behaviorome: Comprehensive, quantitative, and unbiased visualization of defined behavior states
4370Lieber, Charles M.Cyborg tissue: Macroporous nanowire nanoelectronic scaffolds for synthetic tissues
4342Mekalanos, John J.High efficency di-nucleotide cyclase
4324Cohen, Adam E.Voltage indicator proteins and microscope for imaging rhodopsin fluorescence
4238Eggan, Kevin CarlInduced motor neurons (iMNs)
4223Salic, AdrianMethod for imaging and identifying newly synthesized proteins in vivo
4214Knipe, David M.New herpes drug target and candidate
4197Liu, David R.Directed evolution of bond-forming enzymes using yeast display: application to sortase A
4173Lange, ChristophSpeedGene -- a compression algorithm for the fast and efficient storage of next generation genetic sequence data in an existing hardware environment
4095Park, HongkunLow voltage nanowire-based electroporation of cells
4086Liu, David R.Zinc-finger nucleases: determining and improving target sequence specificity
4068Lory, StephenDEVELOPMENT OF BROAD SPECTRUM ANTIMICROBIAL AGENTS; TARGETING THE CELL ENVELOPE BIOGENESIS PATHWAY OF GRAM-NEGATIVE; BACTERIAL PATHOGENS
4020Perrimon, Norbert J.In vivo drug screening in Drosophila for cancer stem cells
3867Hotamisligil, Gokhan S.Novel lipid hormone for identifying and treating metabolic disease
3826Cohen, Adam E.A fast, sensitive optical indicator for membrane potential in cells
3786Mooney, David J.Materials presenting Notch signaling molecules to control cell behavior
3760Doyle, John M.Analyzing trace gases at part per billion levels by rapid gas phase cooling
3741McMahon, Andrew P.Modulators of hedgehog signaling
3733Whitesides, George M.Uniform phage display amplification in droplets
3718Whitesides, George M.3D cell culture substrate that enables live-cell imaging
3696Lu, QuanNew therapeutic targets for the treatment of asthma and COPD
3678Colaiacovo, Monica P.High-throughput screening tools for environmental disruptors of meiosis and fat homeostasis
3605Melton, DouglasIDE1 and IDE2, small molecule inducers of definitive endoderm from mouse and human embryonic stem cells
3602Olsen, Bjorn R.Vascular endothelial transdifferentiation to mesenchymal stem-like cells
3580Liu, David R.Interaction-dependent PCR: Multiplexed identification of ligand-target pairs from DNA-encoded ligand/target libraries in a single solution-phase experiment
3578Ritter, TobiasLate-stage fluorination of biomedically-active molecules
3569Roth, Frederick P.Novel combination therapies for the treatment of cancer and inflammation
3549Greenberg, Michael ENovel target for Angelman Syndrome and Autism Spectrum Disorders
3538Sabatini, BernardoPhotoactivatable opoid neuropeptides
3507Lieber, Charles M.Localized bioprobes for electrophysiology
3495Wu, Chao-tingOligopaints as a means for marking chromosomes with superior resolution and labeling functionality
3473Nagai, ShigemiOsteoinductive peptides to enhance bone regeneration
3469Sorger, Peter K.Knockout mouse model for human liver cancer
3468Crozier, Kenneth B.The SMALL Microscope: Scanning microscopy on a chip
3466Mazur, EricFast, accurate, laser-based cell injection technique
3438Walker Kahne, SuzannePotent OGT inhibitors for the treatment of cancer and diabetic complications
3437Salic, AdrianMetabolic labeling and direct imaging of choline-containing phospholipids in vivo
3378Rubin, Lee L.Methods and compounds for the treatments of spinal muscular atrophy and ALS
3350Grusby, Michael J.CD1-deficient mouse
3330Eggan, Kevin CarlEfficient induction of pluripotent stem cells using small molecule compounds: RepSox
3326Liu, David R.A system for the continuous directed evolution of biomolecules
3312Melton, DouglasMethods of direct reprogramming: converting pancreatic exocrine cells to beta cells
3263Sanes, Joshua R.Anti-Dscam monoclonal antibodies for studying the establishment of neural circuits
3262Hotamisligil, Gokhan S.Novel lipid hormone for identifying and treating metabolic disease
3237Mazur, EricThe key to getting good Raman data - separating "hot" nanoparticles for signal enhancement
3231Whitesides, George M.Paper-supported 3D cell culture for cell and tissue-based bioassays
3219Myers, Andrew G.Synthetic route for anti-angiogenic natural products cortistatins and analogs
3216Schreiber, Stuart L.Robotnikinin: small molecule inhibitor of sonic hedgehog (Shh) signaling in human cells
3211Park, HongkunVertical silicon nanowires as a universal platform for highly efficient delivery of bioactive molecules into living cells
3205Eggan, Kevin CarlInduced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
3198Prentiss, Mara G.New cell sorting technology could replace fluorescent and magnetic technologies
3197Melton, DouglasUsing (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage
3189Wong, Wesley PhilipInstrument for massively parallel single molecule binding measurements
3175Tschumperlin, Daniel J.High-throughput hydrogel-based 2D platform for culturing cells in realistic tissue stiffness environments
3152Melton, DouglasEfficient induction of pluripotent stem cells using small molecule compounds
3146Mazitschek, RalphHDAC substrate is ideally suited to HDAC 4, 5, 7, 8 and 9 enzyme activity assays
3086Corey, David P.TRPA1 constitutive and conditional knockout mice
3045Crozier, Kenneth B.Optical tweezers get smaller, sharper, and less expensive
3025Schier, Alexander FRNA therapy: miRNA target protectors
2985Kahne, Daniel E.Development of broad spectrum antibiotics for new targets
2983Fredberg, JeffreyRealistic reproduction of a cell's dynamic physical environment
2964Eggan, Kevin CarlIn vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)
2963Gygi, Steven P.Mass spectrometry-based in vitro kinome activity assay
2956Roth, Frederick P.Methods and applications for stitched DNA barcodes
2944McMahon, Andrew P.Wnt ligands for the development of diagnostics and treatments of CNS and BBB disorders
2905Chou, James J.DNA nanotube liquid crystals for NMR structure determination
2889Sanes, Joshua R.Corticospinal tract (CST)-YFP transgenic mice for monitoring axonal responses to spinal cord injury
2807Maniatis, ThomasHomozygous IKKepsilon knockout mouse as an animal model for influenza virus infection
2768Weitz, David A.Novel surfactants for stabilizing emulsions of water or hydrocarbon oil-based droplets in a fluorocarbon oil continuous phase
2756Sanes, Joshua R.Anti-SAD-A monoclonal antibody for studying pre-synaptic differentiation and neuronal polarization
2715Whitesides, George M.Antibody purification
2704Walker Kahne, SuzanneDevelopment of broad spectrum antibiotics for new targets
2681Wessling-Resnick, MarianneHEK293T cells stably express Divalent Metal Transporter-1 for use in a model system to screen for inhibitors of iron uptake
2639Larson, Dale N.Smaller and faster biocalorimeter for ultra-sensitive temperature sensing that helps reduce drug-development cost and risk
2633Pizzagalli, Diego A.Software for early detection and assessment of depression
2627Bonni, AzadTargeting MEF2A for the treatment of neurodegenerative disease
2612Lichtman, Jeffrey W.Transgenic mice with fluorescently tagged neuronal mitochondria as a new tool to study axonal transport
2611Lichtman, Jeffrey W.Brainbow mice: A technicolor approach to map the neuronal circuits
2568Whelan, Sean P.J.Attenuated RNA viruses for vaccine and drug delivery
2559McMahon, Andrew P.A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo
2438Myers, Andrew G.Natural product avrainvillamide and its analogs as targeted anticancer agents
2436Schreiber, Stuart L.Tubacin - a specific small molecule inhibitor of HDAC6 tubulin deacetylase activity
2406Roth, Frederick P.Simultaneous study of multiple genetic interactions using multi-mutant yeast
2384Nibert, Max L.Determination of intracellular protein-protein interactions
2334Liu, David R.Small-molecule-triggered intein splicing as a universal switch for protein activation
2307Church, George M.Enhanced fidelity of sub-nanogram amplification
2301Goldberg, Alfred L.Novel candidates for Tuberculosis therapy
2261Church, George M.Modular conditional knockout: Precise temporal control of protein degradation in living cells
2258Church, George M.Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")
2252Rando, Robert R.Treatment of AMD by Targeting Lipocuscin
2215Weitz, David A.Method and apparatus for fluid dispersion
2212Dowling, John E.Using Zebrafish for clues about human vision loss
2203Kobzik, LesterMonoclonal IgE anti-ovalbumin antibody
2193Myers, Andrew G.A novel assay for identifying biological targets of DNA binding agents
2170Hotamisligil, Gokhan S.Animal model of diabetes and obesity
2163Liu, David R.Drug-inducible RNA aptaswitch for regulating eukaryotic protein expression
2161Tsai, Li-HueiTransgenic mouse model for neurodegenerative disease
2144McMahon, Andrew P.Modulating gene activity on chondrocytes
2129Verdine, Gregory L.Lead compounds for the treatment of pain
2126Whitesides, George M.Cell Motility Assay with Spatial and Temporal Control
2060Schreiber, Stuart L.Anti-mitotic Eg5 inhibitors for the treatment of cancer and inflammatory disease
2032Shi, YangA DNA vector-based RNAi technology to suppress gene expression in mammalian cells
2025Liu, David R.In vivo selection systems for evolving the specificity of endonucleases and inteins
2024Church, George M.MicroArray spot LINEar regression (MASLINER) software
1947Roth, Frederick P.GoFish gene annotation and database query software
1918Gygi, Steven P.Absolute quantification of Proteins (AQUA)
1917Schreiber, Stuart L.Tubacin - a specific small molecule inhibitor of HDAC6 tubulin deacetylase activity
1903Coen, Donald M.Sensitive assay to identify inhibitors of HSV DNA polymerase
1885Liu, David R.Directed evolution of proteins and nucleic acids using nonhomologous random recombination
1884Gygi, Steven P.Microcapillary column peptide trap provides superior mechanical design to the automated loader
1882Myrick, Kyl V.A versatile method for accelerated chromosome walking and DNA fingerprinting
1878Whitesides, George M.Selective Deposition of Cells in Microwells
1872Kirschner, Marc W.Targeting FtsZ activity using novel antibacterials
1833Kobzik, LesterAnti-PLK-1 monoclonal antibody
1823Verdine, Gregory L.A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research
1821Church, George M.Time and concentration warping software for RNA and protein expression data
1816Lieber, Charles M.High-yield fabrication of single-walled carbon nanotube probe tips for atomic force microscopy
1781Walsh, Christopher T.Techniques for high yield synthesis of macrocyclic compounds
1740Rubin, Eric JosephHyperactive mutant of the Himar1 mariner transposase
1699Kim, TaeKookp53 cell-Based assay
1690Shair, Matthew D.Ultra fast method for chiral catalyst discovery
1675Schreiber, Stuart L.Human Histone Deacetylase (HDAC) Class II
1659Yuan, Zhi-MinNovel means of protecting the cell against oncogenic tumor formation
1613Coen, Donald M.Inhibitors of protein-processivity factor
1603Falchuk, Kenneth H.Bilins as anticancer agents
1587David, John R.Migration inhibitory factor (MIF) knockout mouse
1554Yuan, JunyingSmall molecule therapeutic for drugs against chronic neural degenerative diseases
1546Knipe, David M.A genetically modified herpes simplex virus that has utility as a drug screening tool
1534Howley, Peter M.Selectively degrading specific cellular proteins
1528Hogle, James M.A tool for the linkage and presentation of multiple protein functional domains
1490Wilcox, Heather M.Monoclonal antibody 2F12, Anti-ITK
1487Schreiber, Stuart L.High-throughput synthetic platform for natural product analog libraries
1486Howley, Peter M.Compositions and methods for treating papillomavirus-infected cells
1475Mekalanos, John J.Systematic, condition-independent identification of essential genes of microorganisms
1472Verdine, Gregory L.Synthesis of compounds with peptide characteristics
1452Shi, ChengweiCellular basis of vascular-graft stenosis
1451Church, George M.AlignAce motif searching software
1441Glimcher, LaurieTranscription HXBP-1 factor fragment
1439Church, George M.Surface-bound double-stranded DNA protein arrays
1438Church, George M.Production and uses of polymerase colony ("polony") arrays
1426Struhl, KevinA rapid and inducible method for repressing gene function
1391Melton, DouglasCell-based assay for the discovery of glycogen synthase kinase inhibitors
1372Whitman, Malcolm R.Methods and reagents for modulating TGF-beta superfamily signalling
1329Beverley, Stephen M.New delivery device for protein therapeutics and vaccines
1250Schreiber, Stuart L.Human Histone Deacetylase (HDAC) Class I
1248Wessling-Resnick, MarianneNovel compositions which modulate iron uptake in cells for the treatment of iron deficient anemias or iron overload disorders
1246Lee, Arthur Mu-EnMediator of arterial smooth muscle cell LIM protein
1188Wong, David T. W.Novel tumor suppressor protein and gene could be used to develop treatments of carcinoma
1173Coen, Donald M.High lead expression of soluble CMV UL97 and development of an assay to screen inhibitors
1127Swanson, JoelLiposome-based, intracellular delivery of drugs into phagocytes, B- and T-cells, and their tumor cells
1119Leder, PhilipEotaxin: an eosinophil chemoattractant
0951Russell, MaryMethods of detecting and treating arterial inflammatory disease
0806Essex, Myron EA method for producing partially deglycosylated HIV-1 envelope glycoproteins through site-directed mutagenesis
0627Berson, EliotProbe compositions and relevant animal models used to evaluate the pathogenesis of retinitis pigmentosa and potentially new therapeutic modalities