Harvard University Office of Technology Development Collaborative Research Opportunity Finder

1. Jose Halperin, MD

   Targeting protein translation for anticancer therapies; CD59 and diabetes

   Employ the preclinical resources of the Laboratory for Translational Research to develop new therapies and diagnostics in oncology and diabetes

   

2. Andrew McMahon, PhD

   Developmental and Regenerative Biology

   Investigating the molecular and cellular mechanisms regulating development, repair and regeneration of neural, bone and kidney tissues.

   

3. David Sinclair, PhD

   Sirtuins in aging and disease: calorie restriction; mitochondria; cancer; diabetes

   Study sirtuin pathways, their role in multiple diseases and their lifespan extension capabilities.

   

4. Bruce Yankner, MD, PhD

   Molecular mechanisms of aging and aging-related neurodegenerative diseases

   Explore aging at the molecular level, employing a systems biology approach

   

Research Categories

Research Tools and Instrumentation

Therapeutic Discovery Tools and Assays

Sub-categories

1. Drug Development: Methodologies

   1. $1000 genome»
   2. Antiretrovirals»
   3. Atherosclerosis»
   4. Biomarker»
   5. Cancer drug targets»
   6. Cardiac function»
   7. Cell senescence»
   8. Combination index»
   9. Combination therapy»
   10. Combinatorial selectivity»
   11. Computational modeling»
   12. Data mining»
   13. Disease pathway modeling»
   14. Disease targets»
   15. Dose prediction»
   16. Drug specificity»
   17. dsRNA therapeutics»
   18. Gene therapy»
   19. High throughput»
   20. In silico molecular modeling»
   21. In vitro biochemical assays»
   22. Mechanism-based toxicity»
   23. Mouse models»
   24. NeuroD»
   25. Neuropharmacology»
   26. Non-invasive therapy»
   27. Patient-specific therapy»
   28. Personalized medicine»
   29. Pharmacokinetics»
   30. Protein and small molecule production»
   31. Radiotherapy»
   32. RNAi»
   33. Targeted therapy»
   34. Technology development»

2. Research Tools; Animal and Cell Models; Unique Resources

   1. 3-dimensional basement membrane cell cultures»
   2. Adeno-associated virus (AAV)»
   3. Alexa Fluor dyes»
   4. Artificial tether»
   5. Auditory enrichment»
   6. Automated zebrafish screening»
   7. Automation»
   8. Behavior model»
   9. Biocomputational methods»
   10. Bioinformatics»
   11. Brain plasticity»
   12. Brainbow system»
   13. C. elegans»
   14. Ca2+-GFP-Aequorin»
   15. Calcium indicators»
   16. cDNA libraries from single neurons»
   17. cell culture in linear micro-colonies»
   18. Cell-based assays»
   19. Cellular ablation»
   20. Computer-assisted image analysis»
   21. Cryo-Electron Tomography»
   22. Cyanobacteria»
   23. Drosophila»
   24. Drosophila RNAi Screening Center»
   25. Escape behavior»
   26. Escherichia coli (E. coli)»
   27. FACS analysis»
   28. Genetically-encoded biosensor»
   29. Genome mining»
   30. High resolution transcriptome sequencing»
   31. High Throughput Screening»
   32. Human cells»
   33. Insomnia model»
   34. Interactive computer software»
   35. Knockout mouse»
   36. Lab-On-A-Chip»
   37. Mammalian cells»
   38. Microorganism»
   39. Molecular modeling»
   40. Monkey»
   41. Mouse behavior»
   42. Mouse imaging»
   43. Mouse models»
   44. Mouse tumor models»
   45. Multiphoton laser scanning microscopy»
   46. Natural host»
   47. Neuronal recordings»
   48. Non-human primate»
   49. Odor map»
   50. Odor-guided perceptual decision task»
   51. OMP-ChR2 mice»
   52. Optogenetics»
   53. Physics»
   54. Primate Model»
   55. Protein and small molecule production»
   56. Rabies vector»
   57. Recombinant toxins»
   58. Retrogenic mouse»
   59. Retroviral vector»
   60. Reward-based decision making and learning»
   61. Reward-based learning and decision-making assays»
   62. Rhesus macaque»
   63. S. cerevisiae»
   64. S. pombe»
   65. Short and long-term olfactory memory tests»
   66. Sooty mangabey»
   67. SpH mice»
   68. Tissue engineering»
   69. Transcriptome comparisons»
   70. Transgenic mice»
   71. Transgenic mouse»
   72. Transgenic zebrafish»
   73. Video microscopy»
   74. Visual deprivation»
   75. Widefield FCS»
   76. Xenopus tadpoles»
   77. Yeast»
   78. Yeast microbiology»
   79. Zebrafish larvae»
   80. Zebrafish models»