Signal transduction: nutrient and energy sensing; disease; mTOR; PI3-kinase; Ras
Explore the diverse yet overlapping intracellular transmission signals propagated by cell surface receptors that respond to extracellular growth factors, environmental conditions, and other ...
Neuronal cell development; glioblastoma
Investigate key intracellular signaling pathways in neuronal cell development and maturation as well as in brain tumors such as glioblastoma
Structural biology of retroviruses
The D’Souza laboratory investigates the structural basis of retroviral replication, including the initiation of reverse transcription and translation of viral genes. Understanding the ...
Fundamental cell biological processes: autophagy, protein aggregation and aging, secretory pathways
Investigate the mechanisms of post-translational targeting pathways used to deliver membrane proteins to their appropriate cellular organelle; Define the mechanisms that lead to enhanced formation of ...
Molecular signaling in inflammation: TNF; cytokine; autoimmune disease; T-cell
Investigate the biochemical signaling perturbations elicited by the pro-inflammatory cytokine TNF that serve to modulate the activation of NF-кB, with a focus on TNF receptor-associated factor ...
Ubiquitin-dependent protein degradation and the proteasome: mechanisms and coordination; architecture; role in disease
Study of proteasome activity and its relationship to diseases caused by proteinopathies.
Experimental and theoretical analysis of signal transduction: EGF signaling, drug efficacy, phosphorylation states, microfluidics, formalized biology language
Investigate the dynamics of signal transduction, from a mechanistic and practical perspective. Describe at a fundamental level the input/output transformation that connects external signals to ...
Mitochondrial dysfunction in aging and disease: bioenergetics, metabolomics, and cell stress
Study the role of the sirtuins in metabolism, aging, and disease
Targeting protein translation for anticancer therapies; CD59 and diabetes
Employ the preclinical resources of the Laboratory for Translational Research to develop new therapies and diagnostics in oncology and diabetes
Investigate the activities of papillomavirus-encoded proteins, including the E6-mediated degradation of p53 and E2-mediated regulation of viral transcription and genome replication
Radiolabeled small molecule prodrugs for non-invasive cancer imaging and therapy
Development of Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) as a new paradigm for noninvasive radioimaging and radiotherapy (ß- and alpha-particle emitting radionuclides) of solid ...
The p53 tumor suppressor as a model for studying temporal dynamics of signaling networks
Investigate protein dynamics at the single cell level; quantification of proteins in live cells using fluorescence microscopy and mathematical modeling; cellular decision-making in cancer and healthy ...
Cellular function and evolution using Saccharomyces cerevisiae
Examining budding yeast (Saccharomyces cerevisiae) from the perspective of both biology and physics, investigate the mechanics of how genetic information is transferred during cell division and ...
Cellular signaling pathways and regulation of gene expression
Studies of how cells are monitoring the environment and the resulting response via regulation of gene expression in simple model organisms. Investigates the evolution of transcription regulation; ...
Modeling developmental processes and signaling pathways in Drosophila
Use Drosophila as a model organism to explore basic biological mechanisms of development and cellular signaling, with a focus on muscle physiology.
Immune modulation to treat cancer and viral infections
CD59, the complement cascade, and disease
Hedgehog signaling and cell-cell communication
Post-translation modification with cholesterol; regulation of transcription
Histone demethylation and gene regulation: gene expression; epigenetics; disease
Studies on lysine-specific demethylases and biochemical and functional aspects of histone demethylation.
Sirtuins in aging and disease: calorie restriction; mitochondria; cancer; diabetes
Study sirtuin pathways, their role in multiple diseases and their lifespan extension capabilities.
Systems biology applied to disease mechanisms and drug therapy
Translate activity-based proteomic data and computational modeling into practical applications for cancer therapies, inflammation studies, and personalized medicine.
Eukaryotic Transcriptional Regulation
Investigate basic mechanisms of gene regulation in yeast; Employ mammalian cell models of tumorigenesis to elucidate genetic changes that underlie cancer development and progression
Host response to viral infection and drug discovery: dengue virus, hepatitis B and C viruses
Investigate molecular mechanisms of dengue and hepatitis virus infection and replication; perform HTS for viral antagonists to identify host factors and pathways required for dengue virus infection ...
Clinical Disorders and Disease Etiology
- Age-related macular degeneration (AMD)»
- Alzheimerís disease»
- Amyloid plaque»
- Amyloid precursor protein (APP)»
- Amyotrophic Lateral Sclerosis (ALS)»
- Autoimmune disease»
- Bacterial infection»
- Behavioral disorders»
- Brain disease»
- Breast cancer»
- Cardiovascular disease»
- Cervical cancer»
- Chronic viral infection»
- Circadian rhythm»
- Complex disease»
- Contact hypersensitivity»
- Cystic fibrosis lung infection»
- Cytoskeletal disease»
- Dengue fever»
- Dengue hemorrhagic fever»
- Dengue Virus»
- Developing country»
- Disease genes»
- Disease prognosis»
- Down syndrome»
- Drug abuse»
- Ebola virus»
- Emerging infections»
- Epithelial tumor»
- Hearing loss»
- Hepatitis B»
- Hepatitis C»
- Hepatocellular carcinoma»
- Herpes simplex virus»
- Huntingtonís disease»
- Infectious disease»
- Klinefelterís syndrome»
- Lentivirus infection»
- Liver cancer»
- Marburg virus»
- Membrane-enveloped viruses»
- Metabolic disease»
- Mitochondrial dysfunction»
- Mosquito-borne illness»
- Nervous system disorders»
- Neurodegenerative disease»
- Neurological disease»
- Neurological disorders»
- Olfactory dysfunction»
- Opportunistic pathogen»
- Organ transplant rejection»
- Ovarian cancer»
- Parkinsonís disease»
- Post-traumatic stress disorder (PTSD)»
- Prostate cancer»
- Retinal degeneration»
- Retinal disorders»
- Retinal telangiectasia»
- Retinitis Pigmentosa»
- Side effects»
- SIV encephalitis»
- Spinal Muscular Atrophy (SMA)»
- Tropical disease»
- Turner syndrome»
- Vascular disease»
- Viral infection»
- Virus entry»
- X-linked mental retardation»