Keyword(s): Cancer

  1. John Blenis, PhD

    Signal transduction: nutrient and energy sensing; disease; mTOR; PI3-kinase; Ras

    Explore the diverse yet overlapping intracellular transmission signals propagated by cell surface receptors that respond to extracellular growth factors, environmental conditions, and other ...

  2. Azad Bonni, MD, PhD

    Neuronal cell development; glioblastoma

    Investigate key intracellular signaling pathways in neuronal cell development and maturation as well as in brain tumors such as glioblastoma  

  3. Victoria D'Souza, PhD

    Structural biology of retroviruses

    The D’Souza laboratory investigates the structural basis of retroviral replication, including the initiation of reverse transcription and translation of viral genes. Understanding the ...

  4. Vlad Denic, PhD

    Fundamental cell biological processes: autophagy, protein aggregation and aging, secretory pathways

    Investigate the mechanisms of post-translational targeting pathways used to deliver membrane proteins to their appropriate cellular organelle; Define the mechanisms that lead to enhanced formation of ...

  5. Martin Dorf, PhD

    Molecular signaling in inflammation: TNF; cytokine; autoimmune disease; T-cell

    Investigate the biochemical signaling perturbations elicited by the pro-inflammatory cytokine TNF that serve to modulate the activation of NF-кB, with a focus on TNF receptor-associated factor ...

  6. Daniel Finley, PhD

    Ubiquitin-dependent protein degradation and the proteasome: mechanisms and coordination; architecture; role in disease

    Study of proteasome activity and its relationship to diseases caused by proteinopathies.

  7. Jeremy Gunawardena, PhD

    Experimental and theoretical analysis of signal transduction: EGF signaling, drug efficacy, phosphorylation states, microfluidics, formalized biology language

    Investigate the dynamics of signal transduction, from a mechanistic and practical perspective. Describe at a fundamental level the input/output transformation that connects external signals to ...

  8. Marcia Haigis, PhD

    Mitochondrial dysfunction in aging and disease: bioenergetics, metabolomics, and cell stress

    Study the role of  the sirtuins in metabolism, aging, and disease

  9. Jose Halperin, MD

    Targeting protein translation for anticancer therapies; CD59 and diabetes

    Employ the preclinical resources of the Laboratory for Translational Research to develop new therapies and diagnostics in oncology and diabetes

  10. Peter Howley, MD

    Papillomavirus biology

    Investigate the activities of papillomavirus-encoded proteins, including the E6-mediated degradation of p53 and E2-mediated regulation of viral transcription and genome replication

  11. Amin Kassis, PhD

    Radiolabeled small molecule prodrugs for non-invasive cancer imaging and therapy

    Development of Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) as a new paradigm for noninvasive radioimaging and radiotherapy (ß- and alpha-particle emitting radionuclides) of solid ...

  12. Galit Lahav, PhD

    The p53 tumor suppressor as a model for studying temporal dynamics of signaling networks

    Investigate protein dynamics at the single cell level; quantification of proteins in live cells using fluorescence microscopy and mathematical modeling; cellular decision-making in cancer and healthy ...

  13. Andrew Murray, PhD

    Cellular function and evolution using Saccharomyces cerevisiae

    Examining budding yeast (Saccharomyces cerevisiae) from the perspective of both biology and physics, investigate the mechanics of how genetic information is transferred during cell division and ...

  14. Erin O'Shea, PhD

    Cellular signaling pathways and regulation of gene expression

    Studies of how cells are monitoring the environment and the resulting response via regulation of gene expression in simple model organisms. Investigates the evolution of transcription regulation; ...

  15. Norbert Perrimon, PhD

    Modeling developmental processes and signaling pathways in Drosophila

    Use Drosophila as a model organism to explore basic biological mechanisms of development and cellular signaling, with a focus on muscle physiology.

  16. Xuebin Qin, MD, PhD

    Immune modulation to treat cancer and viral infections

    CD59, the complement cascade, and disease    

  17. Adrian Salic, PhD

    Hedgehog signaling and cell-cell communication

    Post-translation modification with cholesterol; regulation of transcription      

  18. Yang Shi, PhD

    Histone demethylation and gene regulation: gene expression; epigenetics; disease

    Studies on lysine-specific demethylases and biochemical and functional aspects of histone demethylation.  

  19. David Sinclair, PhD

    Sirtuins in aging and disease: calorie restriction; mitochondria; cancer; diabetes

    Study sirtuin pathways, their role in multiple diseases and their lifespan extension capabilities.

  20. Peter Sorger, PhD

    Systems biology applied to disease mechanisms and drug therapy

    Translate activity-based proteomic data and computational modeling into practical applications for cancer therapies, inflammation studies, and personalized medicine.  

  21. Kevin Struhl, PhD

    Eukaryotic Transcriptional Regulation

    Investigate basic mechanisms of gene regulation in yeast; Employ mammalian cell models of tumorigenesis to elucidate genetic changes that underlie cancer development and progression  

  22. Priscilla Yang, PhD

    Host response to viral infection and drug discovery: dengue virus, hepatitis B and C viruses

    Investigate molecular mechanisms of dengue and hepatitis virus infection and replication; perform HTS for viral antagonists to identify host factors and pathways required for dengue virus infection ...