HIV and AIDS: vaccine; persistent immune response
Develop new strategies for blunting viral replication and bolstering the immune system’s ability to eradicate viral-infected T-cell reservoirs.
Molecular signaling in inflammation: TNF; cytokine; autoimmune disease; T-cell
Investigate the biochemical signaling perturbations elicited by the pro-inflammatory cytokine TNF that serve to modulate the activation of NF-кB, with a focus on TNF receptor-associated factor ...
HIV infection and AIDS vaccine development
Investigate new approaches for AIDS vaccine development using SIV infection of non-human primates as a model system.
HIV mechanism of action and new AIDS therapies
Gene therapy; vaccines
AIDS pathogenesis and CMV opportunistic infection: SIV; vaccine; AIDS resistance
AIDS modeling in non-human primates; reactivation of latent CMV in HIV-infected individuals; innate resistance to SIV-related disease progression.
Immune modulation to treat cancer and viral infections
CD59, the complement cascade, and disease
T-cell regulation and disease: chronic viral infection; autoimmunity, tumor immunotherapy, peripheral tolerance
T cell co-stimulation and its immunoregulatory role in controlling the balance between T cell activation and tolerance.
Bacterial infection and acquired immunity
T-cell response to bacterial infection, including sexually transmitted chlamydia disease
Adaptive immunity and leukocyte trafficking: lymphocyte activation; lymphatic system; intravital microscopy
Study how immunological memory is produced through the orchestration of the adaptive immune response, including initiation, regulatory mechanisms, and immune cell homing to organs; harnessing of this ...
Host response to viral infection and drug discovery: dengue virus, hepatitis B and C viruses
Investigate molecular mechanisms of dengue and hepatitis virus infection and replication; perform HTS for viral antagonists to identify host factors and pathways required for dengue virus infection ...
Biologic Specialties (i.e., -ologies; -omics):
- Cell-type specific gene expression»
- Chemical biology»
- Chemical ecology»
- Comparative pathology»
- Computational biology»
- Computational genomics»
- Developmental biology»
- Environmental regulation»
- Functional genomics»
- Genome mining»
- Infectious disease»
- Microbial biology»
- Microbial ecology»
- Microbial genetics»
- Microbial genomics»
- Molecular biology»
- Neural circuits»
- Neuronal cell biology»
- Polymer science»
- Population demographic»
- Retina genetics»
- Retinal metabolism»
- Synthetic biology»
- Systems Biology»
- Tumor biology»
- Vascular biology»