Research Categories - Therapeutic Discovery Tools and Assays

    

Related Investigators

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  1. Daniel Finley, PhD

    Ubiquitin-dependent protein degradation and the proteasome: mechanisms and coordination; architecture; role in disease

    Study of proteasome activity and its relationship to diseases caused by proteinopathies.

  2. Walter Fontana, PhD

    Information biology: principles, limits, and evolution of information processing in molecular systems

    Develop, apply, and establish the concept of programs as models to represent, model, and analyze complex systems of molecular interactions underlying cellular behavior; empirically characterize and ...

  3. Rachelle Gaudet, PhD

    Structural biology of ion channels and transporters

    X-ray crystallography and other biophysical and biochemical techniques are applied to study the stereochemistry of signaling and transport through biological membranes. Research interests include the ...

  4. Jeremy Gunawardena, PhD

    Experimental and theoretical analysis of signal transduction: EGF signaling, drug efficacy, phosphorylation states, microfluidics, formalized biology language

    Investigate the dynamics of signal transduction, from a mechanistic and practical perspective. Describe at a fundamental level the input/output transformation that connects external signals to ...

  5. Marcia Haigis, PhD

    Mitochondrial dysfunction in aging and disease: bioenergetics, metabolomics, and cell stress

    Study the role of  the sirtuins in metabolism, aging, and disease

  6. Jose Halperin, MD

    Targeting protein translation for anticancer therapies; CD59 and diabetes

    Employ the preclinical resources of the Laboratory for Translational Research to develop new therapies and diagnostics in oncology and diabetes

  7. James Hogle, PhD

    Virus structure, mechanism of entry into cells, and replication

    Perform studies on poliovirus infection; investigate the proteomic composition of virus-laden membrane vesicles; study the herpes simplex virus replication complex and nuclear egress ...

  8. Peter Howley, MD

    Papillomavirus biology

    Investigate the activities of papillomavirus-encoded proteins, including the E6-mediated degradation of p53 and E2-mediated regulation of viral transcription and genome replication

  9. Craig Hunter, PhD

    Biogenesis, Transport, and Function of intercellular RNAs

    Understand how the silencing information of RNAi spreads among cells and transmits to the progeny; Investigate the function of intercellular RNA transporters in nematodes and mice and discover ...

  10. Amin Kassis, PhD

    Radiolabeled small molecule prodrugs for non-invasive cancer imaging and therapy

    Development of Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) as a new paradigm for noninvasive radioimaging and radiotherapy (ß- and alpha-particle emitting radionuclides) of solid ...