Ubiquitin-dependent protein degradation and the proteasome: mechanisms and coordination; architecture; role in disease
Study of proteasome activity and its relationship to diseases caused by proteinopathies.
Information biology: principles, limits, and evolution of information processing in molecular systems
Develop, apply, and establish the concept of programs as models to represent, model, and analyze complex systems of molecular interactions underlying cellular behavior; empirically characterize and ...
Structural biology of ion channels and transporters
X-ray crystallography and other biophysical and biochemical techniques are applied to study the stereochemistry of signaling and transport through biological membranes. Research interests include the ...
Experimental and theoretical analysis of signal transduction: EGF signaling, drug efficacy, phosphorylation states, microfluidics, formalized biology language
Investigate the dynamics of signal transduction, from a mechanistic and practical perspective. Describe at a fundamental level the input/output transformation that connects external signals to ...
Mitochondrial dysfunction in aging and disease: bioenergetics, metabolomics, and cell stress
Study the role of the sirtuins in metabolism, aging, and disease
Targeting protein translation for anticancer therapies; CD59 and diabetes
Employ the preclinical resources of the Laboratory for Translational Research to develop new therapies and diagnostics in oncology and diabetes
Virus structure, mechanism of entry into cells, and replication
Perform studies on poliovirus infection; investigate the proteomic composition of virus-laden membrane vesicles; study the herpes simplex virus replication complex and nuclear egress ...
Investigate the activities of papillomavirus-encoded proteins, including the E6-mediated degradation of p53 and E2-mediated regulation of viral transcription and genome replication
Biogenesis, Transport, and Function of intercellular RNAs
Understand how the silencing information of RNAi spreads among cells and transmits to the progeny; Investigate the function of intercellular RNA transporters in nematodes and mice and discover ...
Radiolabeled small molecule prodrugs for non-invasive cancer imaging and therapy
Development of Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) as a new paradigm for noninvasive radioimaging and radiotherapy (ß- and alpha-particle emitting radionuclides) of solid ...