Neuronal electrical signaling, ion channels, pacemaking, and neuropharmacology
Investigate the electrical firing and physiology of neuronal ion channels
Signal transduction: nutrient and energy sensing; disease; mTOR; PI3-kinase; Ras
Explore the diverse yet overlapping intracellular transmission signals propagated by cell surface receptors that respond to extracellular growth factors, environmental conditions, and other ...
Neuronal cell development; glioblastoma
Investigate key intracellular signaling pathways in neuronal cell development and maturation as well as in brain tumors such as glioblastoma
Retina development and pathophysiology
Investigate the mechanisms of the development of different retinal cell types derived from multipotent retinal progenitor cells with a focus on photoreceptor cells; study the pathological loss of ...
Personal Genome Project
Genomic DNA Sequencing Technologies; Gene Synthesis; Biofuel
Isolation and characterization of small molecule natural products; high-throughput screening for novel therapeutics
Discovering small molecule, natural products and their biology; high throughput screening for small molecule chemicals that interfere with microbial and mammalian cell processes.
Structural biology of retroviruses
The D’Souza laboratory investigates the structural basis of retroviral replication, including the initiation of reverse transcription and translation of viral genes. Understanding the ...
Fundamental cell biological processes: autophagy, protein aggregation and aging, secretory pathways
Investigate the mechanisms of post-translational targeting pathways used to deliver membrane proteins to their appropriate cellular organelle; Define the mechanisms that lead to enhanced formation of ...
Molecular signaling in inflammation: TNF; cytokine; autoimmune disease; T-cell
Investigate the biochemical signaling perturbations elicited by the pro-inflammatory cytokine TNF that serve to modulate the activation of NF-кB, with a focus on TNF receptor-associated factor ...
VIRAL ENTRY AND ANTI-VIRAL STRATEGIES
Viral Receptors; HIV Therapy; Dengue Virus; SARS; Ebola Virus
Undertake translational studies geared toward the development of novel peptide mimetic inhibitors of HlV binding to its cell surface receptor, modeled after the CD4 and CCR5 HIV receptor/co-receptor; ...