Research Categories - Therapeutic Discovery Tools and Assays
Innovative DNA sequencing procedures, high throughput screening assays for genetic studies and small molecule inhibitors, and computational analysis of signaling pathways are just some of the methodologies that are being employed for diagnostic and therapeutic discovery purposes.
Related Investigators
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Constance Cepko, PhD
Retina development and pathophysiology
Investigate the mechanisms of the development of different retinal cell types derived from multipotent retinal progenitor cells with a focus on photoreceptor cells; study the pathological loss of ...
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Michael Farzan, PhD
VIRAL ENTRY AND ANTI-VIRAL STRATEGIES Viral Receptors; HIV Therapy; Dengue Virus; SARS; Ebola Virus
Undertake translational studies geared toward the development of novel peptide mimetic inhibitors of HlV binding to its cell surface receptor, modeled after the CD4 and CCR5 HIV receptor/co-receptor; ...
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Walter Fontana, PhD
Information biology: principles, limits, and evolution of information processing in molecular systems
Develop, apply, and establish the concept of programs as models to represent, model, and analyze complex systems of molecular interactions underlying cellular behavior; empirically characterize and ...
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Marcia Haigis, PhD
Mitochondrial dysfunction in aging and disease: bioenergetics, metabolomics, and cell stress
Study the role of the sirtuins in metabolism, aging, and disease
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Ed Harlow, PhD
Molecular mechanisms of cell signaling and applications to cancer biology
Global molecular screening studies to gain insights into the genetic regulation of cancer development and response of cancer cells to chemotherapy
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Amin Kassis, PhD
Radiolabeled small molecule prodrugs for non-invasive cancer imaging and therapy
Development of Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) as a new paradigm for noninvasive radioimaging and radiotherapy (ß- and alpha-particle emitting radionuclides) of solid ...
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Xuebin Qin, MD, PhD
Immune modulation to treat cancer and viral infections
CD59, the complement cascade, and disease
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David Sinclair, PhD
Sirtuins in aging and disease: calorie restriction; mitochondria; cancer; diabetes
Study sirtuin pathways, their role in multiple diseases and their lifespan extension capabilities.
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Michael Starnbach, PhD
Bacterial infection and acquired immunity
T-cell response to bacterial infection, including sexually transmitted chlamydia disease
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Chao-ting Wu, PhD
Chromosomal homology, pairing, and segregation: mechanisms and implications for gene therapy, development, and human disease
Explore mechanisms of maintaining genome integrity through the study of chromosomal homology, segregation, and pairing.
