Research Categories - Therapeutic Discovery Tools and Assays

    

Related Investigators

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  1. Bruce Bean, PhD

    Neuronal electrical signaling, ion channels, pacemaking, and neuropharmacology

    Investigate the electrical firing and physiology of neuronal ion channels

  2. John Blenis, PhD

    Signal transduction: nutrient and energy sensing; disease; mTOR; PI3-kinase; Ras

    Explore the diverse yet overlapping intracellular transmission signals propagated by cell surface receptors that respond to extracellular growth factors, environmental conditions, and other ...

  3. Azad Bonni, MD, PhD

    Neuronal cell development; glioblastoma

    Investigate key intracellular signaling pathways in neuronal cell development and maturation as well as in brain tumors such as glioblastoma  

  4. Constance Cepko, PhD

    Retina development and pathophysiology

    Investigate the mechanisms of the development of different retinal cell types derived from multipotent retinal progenitor cells with a focus on photoreceptor cells; study the pathological loss of ...

  5. George Church, PhD

    Personal Genome Project

    Genomic DNA Sequencing Technologies; Gene Synthesis; Biofuel

  6. Jon Clardy, PhD

    Isolation and characterization of small molecule natural products; high-throughput screening for novel therapeutics

    Discovering small molecule, natural products and their biology; high throughput screening for small molecule chemicals that interfere with microbial and mammalian cell processes.  

  7. Victoria D'Souza, PhD

    Structural biology of retroviruses

    The D’Souza laboratory investigates the structural basis of retroviral replication, including the initiation of reverse transcription and translation of viral genes. Understanding the ...

  8. Vlad Denic, PhD

    Fundamental cell biological processes: autophagy, protein aggregation and aging, secretory pathways

    Investigate the mechanisms of post-translational targeting pathways used to deliver membrane proteins to their appropriate cellular organelle; Define the mechanisms that lead to enhanced formation of ...

  9. Martin Dorf, PhD

    Molecular signaling in inflammation: TNF; cytokine; autoimmune disease; T-cell

    Investigate the biochemical signaling perturbations elicited by the pro-inflammatory cytokine TNF that serve to modulate the activation of NF-кB, with a focus on TNF receptor-associated factor ...

  10. Michael Farzan, PhD

    VIRAL ENTRY AND ANTI-VIRAL STRATEGIES Viral Receptors; HIV Therapy; Dengue Virus; SARS; Ebola Virus

    Undertake translational studies geared toward the development of novel peptide mimetic inhibitors of HlV binding to its cell surface receptor, modeled after the CD4 and CCR5 HIV receptor/co-receptor; ...