Research Categories - Therapeutics

The range of studies that address therapeutics is expansive, encompassing biologic and cell-based therapies, small molecules, and diagnostics. Some examples include chimeric proteins for improving targeted therapy, stem cells for treating neurodegenerative diseases, radiolabeled prodrugs designed to offload cytotoxic activity only at the sites of tumors, and novel natural products having antibiotic properties.

Related Investigators

  1. Jeremy Gunawardena, PhD

    Experimental and theoretical analysis of signal transduction: EGF signaling, drug efficacy, phosphorylation states, microfluidics, formalized biology language

    Investigate the dynamics of signal transduction, from a mechanistic and practical perspective. Describe at a fundamental level the input/output transformation that connects external signals to ...

  2. Jose Halperin, MD

    Targeting protein translation for anticancer therapies; CD59 and diabetes

    Employ the preclinical resources of the Laboratory for Translational Research to develop new therapies and diagnostics in oncology and diabetes

  3. Keith Mansfield, DVM

    Infectious diseases and aging: simian AIDS; opportunistic infection; diet

    Infectious diseases, aging, and dietary intervention.

  4. Samara Reck-Peterson, PhD

    Intracellular cargo movement: the role of molecular motors

    Explore the role of dynein in molecular cargo transport

  5. Peter Sorger, PhD

    Systems biology applied to disease mechanisms and drug therapy

    Translate activity-based proteomic data and computational modeling into practical applications for cancer therapies, inflammation studies, and personalized medicine.  

  6. Roger Spealman, PhD

    CNS disorders: addiction; Parkinson’s disease

    Studies on the mechanisms and efficacy of psychoactive drugs  

  7. Michael Starnbach, PhD

    Bacterial infection and acquired immunity

    T-cell response to bacterial infection, including sexually transmitted chlamydia disease

  8. Fred Winston, PhD

    Mechanisms of eukaryotic gene expression in yeast: transcriptional regulation; chromatin structure

    Employs yeast as a model organism to study mechanisms of eukaryotic transcriptional regulation.  

  9. Priscilla Yang, PhD

    Host response to viral infection and drug discovery: dengue virus, hepatitis B and C viruses

    Investigate molecular mechanisms of dengue and hepatitis virus infection and replication; perform HTS for viral antagonists to identify host factors and pathways required for dengue virus infection ...

  10. Bruce Yankner, MD, PhD

    Molecular mechanisms of aging and aging-related neurodegenerative diseases

    Explore aging at the molecular level, employing a systems biology approach