Research Categories - Metabolism; Metabolic Disease and Aging
Fundamental cell biological processes: autophagy, protein aggregation and aging, secretory pathways
Investigate the mechanisms of post-translational targeting pathways used to deliver membrane proteins to their appropriate cellular organelle; Define the mechanisms that lead to enhanced formation of ...
Neural basis of behaviors in vertebrates
Identify the neural circuits that control specific behaviors in vertebrates; Examine these neural circuits in molecular and cellular detail to understand how neural activity controls innate behavior.
Information biology: principles, limits, and evolution of information processing in molecular systems
Develop, apply, and establish the concept of programs as models to represent, model, and analyze complex systems of molecular interactions underlying cellular behavior; empirically characterize and ...
Mitochondrial dysfunction in aging and disease: bioenergetics, metabolomics, and cell stress
Study the role of the sirtuins in metabolism, aging, and disease
Brain information processing and synaptic architecture
Synapses are the main information processing sites in the brain. Defects in their function underlie many neurological and behavioral disorders, and there is increasing evidence that many of these ...
Systems and synthetic biology: gene expression; synthetic proteins; biofuel
Investigate a wide spectrum of biological phenomena. Starting with gene regulation as a core theme, investigate nuclear spatial architecture, synthetic biology, epigenetics, systems biology, ...
Sirtuins in aging and disease: calorie restriction; mitochondria; cancer; diabetes
Study sirtuin pathways, their role in multiple diseases and their lifespan extension capabilities.
Biological mechanisms of circadian clocks and their roles in metabolic processes
Investigate molecular mechanisms of circadian clocks in the brain, retina, and peripheral tissues
Neuropathology of HIV and SIV infections and AIDS
Explore the molecular and cellular bases of neuropathologies associated with HIV and SIV infections, including encephalitis and dementia.
Mechanisms of eukaryotic gene expression in yeast: transcriptional regulation; chromatin structure
Employs yeast as a model organism to study mechanisms of eukaryotic transcriptional regulation.