Hedgehog signaling and cell-cell communication
Post-translation modification with cholesterol; regulation of transcription
Histone demethylation and gene regulation: gene expression; epigenetics; disease
Studies on lysine-specific demethylases and biochemical and functional aspects of histone demethylation.
Systems and synthetic biology: gene expression; synthetic proteins; biofuel
Investigate a wide spectrum of biological phenomena. Starting with gene regulation as a core theme, investigate nuclear spatial architecture, synthetic biology, epigenetics, systems biology, ...
Sirtuins in aging and disease: calorie restriction; mitochondria; cancer; diabetes
Study sirtuin pathways, their role in multiple diseases and their lifespan extension capabilities.
Systems biology applied to disease mechanisms and drug therapy
Translate activity-based proteomic data and computational modeling into practical applications for cancer therapies, inflammation studies, and personalized medicine.
Eukaryotic Transcriptional Regulation
Investigate basic mechanisms of gene regulation in yeast; Employ mammalian cell models of tumorigenesis to elucidate genetic changes that underlie cancer development and progression
NMR spectroscopy for analyzing protein structure/function relationships; small molecule screening
Study protein structure and small molecule binding to proteins, using NMR spectroscopy and other complementary methods
Mechanisms of eukaryotic gene expression in yeast: transcriptional regulation; chromatin structure
Employs yeast as a model organism to study mechanisms of eukaryotic transcriptional regulation.
Chromosomal homology, pairing, and segregation: mechanisms and implications for gene therapy, development, and human disease
Explore mechanisms of maintaining genome integrity through the study of chromosomal homology, segregation, and pairing.
Host response to viral infection and drug discovery: dengue virus, hepatitis B and C viruses
Investigate molecular mechanisms of dengue and hepatitis virus infection and replication; perform HTS for viral antagonists to identify host factors and pathways required for dengue virus infection ...