Research Categories - Research Tools and Instrumentation
Related Investigators
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Jonathan Beckwith, PhD
Study cellular processes in bacteria: protein folding, reduction and formation of protein disulfide bonds, membrane protein dynamics
Investigate fundamental molecular processes, including protein folding and disulfide bond formation, using E. coli as a model system

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Howard Berg, PhD
Bacterial Motility: Motor Response Based on Sensory Input
The Berg lab studies the motile behavior of bacteria in order to understand how cells sense and respond to changes in their environment. Processing external cues is a problem encountered by ...

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John Blenis, PhD
Signal transduction: nutrient and energy sensing; disease; mTOR; PI3-kinase; Ras
Explore the diverse yet overlapping intracellular transmission signals propagated by cell surface receptors that respond to extracellular growth factors, environmental conditions, and other ...

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Joan Brugge, PhD
Epithelial cell biology; mechanisms of breast and ovarian cancer development
The biology of epithelial cells and tissues, with an emphasis on mammary gland morphogenesis and breast and ovarian cancer

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Constance Cepko, PhD
Retina development and pathophysiology
Investigate the mechanisms of the development of different retinal cell types derived from multipotent retinal progenitor cells with a focus on photoreceptor cells; study the pathological loss of ...

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James Chou, PhD
NMR spectroscopy and membrane protein structure; viral ion channels; antiviral compounds
Apply advanced technologies to the reconstitution and structural biochemistry of membrane proteins, with a focus on viral ion channels; analyze the structure of membrane proteins at the level of ...

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George Church, PhD
Personal Genome Project
Genomic DNA Sequencing Technologies; Gene Synthesis; Biofuel

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Jon Clardy, PhD
Isolation and characterization of small molecule natural products; high-throughput screening for novel therapeutics
Discovering small molecule, natural products and their biology; high throughput screening for small molecule chemicals that interfere with microbial and mammalian cell processes.

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Philippe Cluzel, PhD
Real-time analysis of signal transduction and genetic networks at the single cell level
Investigating genome-wide transcriptional dynamics, and studying multi-drug resistance in bacteria.

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Victoria D'Souza, PhD
Structural biology of retroviruses
The D’Souza laboratory investigates the structural basis of retroviral replication, including the initiation of reverse transcription and translation of viral genes. Understanding the ...

Sub-categories
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Analytic instrumentation – technology and methodology development
- 2D nanowire transistor arrays»
- Automation»
- Computer-assisted image analysis»
- Electroporation»
- Flow cytometry»
- Fluorescence correlation spectroscopy»
- Fluorescent microscopy»
- High resolution transcriptome sequencing»
- Image analysis»
- Live cells imaging»
- Microarray Electrophysiology»
- Microscopy»
- Microtomes»
- Multiphoton laser scanning microscopy»
- Neuronal recordings»
- NMR»
- Total internal reflection microscopy»
- Video microscopy»
- Widefield FCS»
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Biosensors
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Molecular Techniques and Experimental Approaches
- 3-dimensional basement membrane cell cultures»
- Atomic resolution»
- Automated DNA sequencing»
- Biofuel»
- Biomarker»
- BRET»
- Cancer therapy»
- Cell cycle arrest»
- Chemical detection of cell proliferation»
- ChIP»
- Chromatin immunoprecipitation»
- Computational infrastructure/tools»
- Computational modeling»
- Conditional targeted cell ablation»
- Cross-fire irradiation»
- Cryoelectron microscopy»
- Cryoelectron tomography»
- Data mining»
- DNA nanotechnology»
- DNA sequencing»
- Experimental yeast genetics»
- Extinction therapy»
- FISH»
- Fluorescent imaging of cell proliferation»
- Fluorescent In Situ Hybridization»
- FRET»
- Gene knockdown»
- Gene therapy»
- Genetic engineering»
- Genetic pulldown»
- Genetic screen»
- Genome mining»
- Global molecular profiling»
- Heterologous protein expression»
- High resolution structure»
- High throughput»
- Humanized yeast»
- Immune reconstitution»
- Immunotherapy»
- In silico molecular modeling»
- Liposome»
- Live cell imaging»
- Live cells imaging»
- luciferase»
- Mathematical modeling»
- Membrane protein reconstitution»
- Methods development»
- Microarray»
- Microfluidics»
- Molecular modeling»
- Molecular sensor»
- Multiplexing»
- Natural products»
- NMR spectroscopy»
- Optogenetics»
- Patch clamping»
- Personal genome»
- Phenotypic screen»
- Polony DNA sequencing»
- Probabilistic decision tree»
- Radioiodination»
- Radionuclide»
- Recombinant viral vector»
- RNA inhibition»
- RNA interference»
- RNAi»
- Single molecule imaging»
- Single-cell measurement»
- Single-cycle SIV»
- siRNA screen»
- Stem cell gene therapy»
- Synthetic biology»
- Technology development»
- Tissue engineering»
- Tumor immunotherapy»
- Viral entry imaging»
- Virus-membrane complex reconstitution»
- X-ray crystallography»
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NMR and Microscopy Expertise
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Research Tools; Animal and Cell Models; Unique Resources
- 3-dimensional basement membrane cell cultures»
- Adeno-associated virus (AAV)»
- Alexa Fluor dyes»
- Artificial tether»
- Auditory enrichment»
- Automated zebrafish screening»
- Automation»
- Behavior model»
- Biocomputational methods»
- Bioinformatics»
- Brain plasticity»
- Brainbow system»
- C. elegans»
- Ca2+-GFP-Aequorin»
- Calcium indicators»
- cDNA libraries from single neurons»
- cell culture in linear micro-colonies»
- Cell-based assays»
- Cellular ablation»
- Computer-assisted image analysis»
- Cryo-Electron Tomography»
- Cyanobacteria»
- Drosophila»
- Drosophila RNAi Screening Center»
- Escape behavior»
- Escherichia coli (E. coli)»
- FACS analysis»
- Genetically-encoded biosensor»
- Genome mining»
- High resolution transcriptome sequencing»
- High Throughput Screening»
- Human cells»
- Insomnia model»
- Interactive computer software»
- Knockout mouse»
- Lab-On-A-Chip»
- Mammalian cells»
- Microorganism»
- Molecular modeling»
- Monkey»
- Mouse behavior»
- Mouse imaging»
- Mouse models»
- Mouse tumor models»
- Multiphoton laser scanning microscopy»
- Natural host»
- Neuronal recordings»
- Non-human primate»
- Odor map»
- Odor-guided perceptual decision task»
- OMP-ChR2 mice»
- Optogenetics»
- Physics»
- Primate Model»
- Protein and small molecule production»
- Rabies vector»
- Recombinant toxins»
- Retrogenic mouse»
- Retroviral vector»
- Reward-based decision making and learning»
- Reward-based learning and decision-making assays»
- Rhesus macaque»
- S. cerevisiae»
- S. pombe»
- Short and long-term olfactory memory tests»
- Sooty mangabey»
- SpH mice»
- Tissue engineering»
- Transcriptome comparisons»
- Transgenic mice»
- Transgenic mouse»
- Transgenic zebrafish»
- Video microscopy»
- Visual deprivation»
- Widefield FCS»
- Xenopus tadpoles»
- Yeast»
- Yeast microbiology»
- Zebrafish larvae»
- Zebrafish models»