Research Categories - Biological Mechanisms and Pathways

   

Related Investigators

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  1. John Flanagan, PhD

    Molecular analysis of axon guidance

    Investigate molecular mechanisms of axonal guidance, including the continuum of axon response to guidance cues, and the corresponding receptor-mediated signaling.  

  2. Walter Fontana, PhD

    Information biology: principles, limits, and evolution of information processing in molecular systems

    Develop, apply, and establish the concept of programs as models to represent, model, and analyze complex systems of molecular interactions underlying cellular behavior; empirically characterize and ...

  3. Rachelle Gaudet, PhD

    Structural biology of ion channels and transporters

    X-ray crystallography and other biophysical and biochemical techniques are applied to study the stereochemistry of signaling and transport through biological membranes. Research interests include the ...

  4. Karine Gibbs, PhD

    Explores Identity and Territory in the Social World of Bacteria

    Investigate the molecular mechanisms underlying the ability of bacterial cells to discriminate self from non-self; study the bacterium Proteus mirabilis, a Gram-negative opportunistic pathogen that ...

  5. Jeremy Gunawardena, PhD

    Experimental and theoretical analysis of signal transduction: EGF signaling, drug efficacy, phosphorylation states, microfluidics, formalized biology language

    Investigate the dynamics of signal transduction, from a mechanistic and practical perspective. Describe at a fundamental level the input/output transformation that connects external signals to ...

  6. Marcia Haigis, PhD

    Mitochondrial dysfunction in aging and disease: bioenergetics, metabolomics, and cell stress

    Study the role of  the sirtuins in metabolism, aging, and disease

  7. Jose Halperin, MD

    Targeting protein translation for anticancer therapies; CD59 and diabetes

    Employ the preclinical resources of the Laboratory for Translational Research to develop new therapies and diagnostics in oncology and diabetes

  8. Takao K. Hensch, PhD

    Critical periods in brain development

    Dr. Hensch’s research focuses on critical periods during brain development and has a broad impact on both basic understanding of cognitive disorders and therapeutic approaches to them. By ...

  9. James Hogle, PhD

    Virus structure, mechanism of entry into cells, and replication

    Perform studies on poliovirus infection; investigate the proteomic composition of virus-laden membrane vesicles; study the herpes simplex virus replication complex and nuclear egress ...

  10. Peter Howley, MD

    Papillomavirus biology

    Investigate the activities of papillomavirus-encoded proteins, including the E6-mediated degradation of p53 and E2-mediated regulation of viral transcription and genome replication